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Tbio
HNRNPUL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

Protein Summary
Description
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378215
  • ENSP00000367460
  • ENSG00000105323
  • ENST00000392006
  • ENSP00000375863
  • ENST00000593587
  • ENSP00000472629
  • ENST00000595018
  • ENSP00000473132
  • ENST00000602130
  • ENSP00000470687

Symbol
  • E1BAP5
  • HNRPUL1
  • E1BAP5
  • E1B-AP5
  • HNRPUL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.99
co-expressed gene
0.98
hub protein
0.9
transcription factor
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.1   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.1   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
4
90.6
alcohol abuse
2
1
2
75.5
liver fibrosis measurement
2
1
2
75.5
urinary albumin to creatinine ratio
2
1
2
34.9
apolipoprotein A 1 measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
90.6
alcohol abuse
2
75.5
liver fibrosis measurement
2
75.5
urinary albumin to creatinine ratio
2
34.9
apolipoprotein A 1 measurement
1
28.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein U like 1
VGNC:10161
456058
Macaque
heterogeneous nuclear ribonucleoprotein U like 1
722135
Mouse
MGI:2443517
232989
Rat
RGD:1307456
361522
Dog
heterogeneous nuclear ribonucleoprotein U like 1
VGNC:53724
476452
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein U like 1
Macaque
heterogeneous nuclear ribonucleoprotein U like 1
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein U like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BUJ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (233)
1 – 10 of 233
HNRNPF
Tbio
Novelty: 0.01833966
Score: 0.988
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.986
Data Source: STRINGDB
SRSF9
Tbio
Novelty: 0.03141615
Score: 0.978
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.975
Data Source: STRINGDB
RBMX
Tbio
Novelty: 0.01705784
Score: 0.971
Data Source: STRINGDB
SF1
Tbio
Novelty: 0.01538883
Score: 0.965
Data Source: STRINGDB
HNRNPH2
Tbio
Novelty: 0.01739858
Score: 0.964
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.961
Data Source: STRINGDB
SNRPB2
Tbio
Novelty: 0.17219587
Score: 0.961
Data Source: STRINGDB
HNRNPA0
Tbio
Novelty: 0.10233768
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.10

PubMed score by year
PubTator Score  10.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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