Tbio HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1

Protein Summary

Description

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9BUJ2
• B3KMW7
• O76022
• Q6ZSZ0
• Q7L8P4
• Q8N6Z4
• Q96G37
• Q9HAL3
• Q9UG75

Gene Name

• HNRNPUL1

Ensembl ID

• ENST00000378215
• ENSP00000367460
• ENSG00000105323
• ENST00000392006
• ENSP00000375863
• ENST00000593587
• ENSP00000472629
• ENST00000595018
• ENSP00000473132
• ENST00000602130
• ENSP00000470687

Symbol

• E1BAP5
• HNRPUL1
• E1BAP5
• E1B-AP5
• HNRPUL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor binding site profile	0.99
co-expressed gene	0.98
hub protein	0.9
transcription factor	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0