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Tbio
POLR3C
DNA-directed RNA polymerase III subunit RPC3

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334163
  • ENSP00000334564
  • ENSG00000186141

Symbol
  • RPC3
  • RPC62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.97
interacting protein
0.86
transcription factor perturbation
0.84
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit C
VGNC:8445
457224
Macaque
RNA polymerase III subunit C
696943
Mouse
MGI:1921664
74414
Rat
RGD:1311545
310685
Dog
RNA polymerase III subunit C
VGNC:44802
483159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit C
Macaque
RNA polymerase III subunit C
Mouse
Rat
Dog
RNA polymerase III subunit C
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUI4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Protein-Protein Interactions (234)
1 – 10 of 234
POLR3GL
Tdark
Family: Enzyme
Novelty: 0.35648533
p_int: 0.999999854
p_ni: 1.45e-7
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.04485332
p_int: 0.999999776
p_ni: 2.24e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999999613
p_ni: 3.87e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999998301
p_ni: 0.000001699
Score: 0.998
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.999955885
p_ni: 0.000044114
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.01817288
p_int: 0.999586994
p_ni: 0.000413006
Score: 0.998
Data Source: BioPlex,STRINGDB
EFEMP1
Tbio
Novelty: 0.00574779
p_int: 0.992066653
p_ni: 0.00793306
p_wrong: 2.87e-7
Data Source: BioPlex
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
p_int: 0.975798815
p_ni: 0.024201183
p_wrong: 3e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
L3HYPDH
Tdark
Family: Enzyme
Novelty: 0.35456591
p_int: 0.908686949
p_ni: 0.084060431
p_wrong: 0.00725262
Score: 0.228
Data Source: BioPlex,STRINGDB
GADD45B
Tbio
Novelty: 0.00611526
p_int: 0.792598774
p_ni: 0.142645774
p_wrong: 0.064755452
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.62

PubMed score by year
PubTator Score  5.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer