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Tbio
BEGAIN
Brain-enriched guanylate kinase-associated protein

Protein Summary
Description
May sustain the structure of the postsynaptic density (PSD).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355173
  • ENSP00000347301
  • ENSG00000183092
  • ENST00000443071
  • ENSP00000411124

Symbol
  • KIAA1446
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.64
tissue sample
0.54
cellular component
0.52
cell line
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
51
age at menarche
1
1
0
2.3
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
51
age at menarche
0
2.3
34.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
brain enriched guanylate kinase associated
467555
Macaque
brain enriched guanylate kinase associated
717758
Mouse
MGI:3044626
380785
Rat
RGD:708347
79146
Dog
brain enriched guanylate kinase associated
VGNC:38429
490859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
brain enriched guanylate kinase associated
Macaque
brain enriched guanylate kinase associated
Mouse
Rat
Dog
brain enriched guanylate kinase associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BUH8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (29)
1 – 10 of 29
CEP170
Tbio
Novelty: 0.05342931
p_int: 0.999980702
p_wrong: 0.000019298
Score: 0.209
Data Source: BioPlex,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.977
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.96
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.921
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.918
Data Source: Reactome,STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.918
Data Source: Reactome,STRINGDB
GRIN2C
Tclin
Family: IC
Novelty: 0.00430771
Score: 0.915
Data Source: Reactome,STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
Score: 0.906
Data Source: Reactome,STRINGDB
GRIN2D
Tclin
Family: IC
Novelty: 0.00457474
Score: 0.903
Data Source: Reactome,STRINGDB
WDR25
Tdark
Novelty: 0.53632123
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.08

PubMed score by year
PubTator Score  2.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer