SPON2
Spondin-2
Protein Summary
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
- ENST00000290902
- ENSP00000290902
- ENSG00000159674
- ENST00000431380
- ENSP00000394832
- ENST00000617421
- ENSP00000483599
- DIL1
- DIL1
- DIL-1
- MINDIN
- M-SPONDIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.76 | ||
tissue sample | 0.68 | ||
cell type or tissue | 0.67 | ||
biological process | 0.6 | ||
gene perturbation | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.99 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.99 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0