Tbio SPON2 Spondin-2

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Spondin-2

Protein Summary

Description

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Uniprot Accession IDs

• Q9BUD6
• D3DVN9
• Q4W5N4
• Q9ULW1

Gene Name

• SPON2

Ensembl ID

• ENST00000290902
• ENSP00000290902
• ENSG00000159674
• ENST00000431380
• ENSP00000394832
• ENST00000617421
• ENSP00000483599

Symbol

• DIL1
• DIL1
• DIL-1
• MINDIN
• M-SPONDIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.76
tissue sample	0.68
cell type or tissue	0.67
biological process	0.6
gene perturbation	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.13   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.13   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (9)

Reactome (8)

PathwayCommons (1)

Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective B3GALTL causes Peters-plus syndrome (PpS)	38 targets	R-HSA-5083635
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with O-glycosylation of proteins	71 targets	R-HSA-3906995
Reactome	Diseases of glycosylation	146 targets	R-HSA-3781865
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)	38 targets	R-HSA-5083635
Disease	1105 targets	R-HSA-1643685
Diseases associated with O-glycosylation of proteins	71 targets	R-HSA-3906995
Diseases of glycosylation	146 targets	R-HSA-3781865
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (17)

Functions (3)

Components (2)

Processes (12)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
antigen binding	Inferred from Electronic Annotation (IEA)	Ensembl
lipopolysaccharide binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

THBS2

Tbio

Novelty: 0.00401454

Score: 0.921

Data Source: STRINGDB

THSD1

Tbio

Novelty: 0.14679078

Score: 0.92

Data Source: STRINGDB

CFP

Tbio

Novelty: 0.00062861

Score: 0.919

Data Source: STRINGDB

THBS1

Tbio

Novelty: 0.00083403

Score: 0.914

Data Source: STRINGDB

SPON1

Tbio

Novelty: 0.00388947

Score: 0.912

Data Source: STRINGDB

ITGB2

Tclin

Novelty: 0.00237551

Score: 0.912

Data Source: STRINGDB

ADAMTSL4

Tbio

Novelty: 0.04959452

Score: 0.91

Data Source: STRINGDB

ADAMTS9

Tbio

Family: Enzyme

Novelty: 0.02029894

Score: 0.908

Data Source: STRINGDB

ADAMTS5

Tchem

Family: Enzyme

Novelty: 0.00480382

Score: 0.907

Data Source: STRINGDB

THSD4

Tbio

Novelty: 0.16828393

Score: 0.907

Data Source: STRINGDB

Publication Statistics

PubMed Score  64.13

PubMed score by year

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PubTator Score  28.68

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWS

1-70

SLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHEVFSAPAVPSGTGQTSAEL

70-140

EVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTV

140-210

TEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEV

210-280

SLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV

280-331

MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHEVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV

Find similar targets by:

Uniprot Keyword

3D-structure
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Immunity
Innate immunity