Protein Classes
Protein Summary
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
- ENST00000290902
- ENSP00000290902
- ENSG00000159674
- ENST00000431380
- ENSP00000394832
- ENST00000617421
- ENSP00000483599
- DIL1
- DIL1
- DIL-1
- MINDIN
- M-SPONDIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 0.76 | ||
tissue sample | 0.68 | ||
cell type or tissue | 0.67 | ||
biological process | 0.6 | ||
gene perturbation | 0.55 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.13 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.13 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (9)
Reactome (8)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (17)
Functions (3)
Components (2)
Processes (12)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (64)
1 – 10 of 64
THBS2
Novelty: 0.00401454
Score: 0.921
Data Source: STRINGDB
THSD1
Novelty: 0.14679078
Score: 0.92
Data Source: STRINGDB
CFP
Novelty: 0.00062861
Score: 0.919
Data Source: STRINGDB
THBS1
Novelty: 0.00083403
Score: 0.914
Data Source: STRINGDB
SPON1
Novelty: 0.00388947
Score: 0.912
Data Source: STRINGDB
ITGB2
Novelty: 0.00237551
Score: 0.912
Data Source: STRINGDB
ADAMTSL4
Novelty: 0.04959452
Score: 0.91
Data Source: STRINGDB
ADAMTS9
Family: Enzyme
Novelty: 0.02029894
Score: 0.908
Data Source: STRINGDB
ADAMTS5
Family: Enzyme
Novelty: 0.00480382
Score: 0.907
Data Source: STRINGDB
THSD4
Novelty: 0.16828393
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score 64.13
PubMed score by year
PubTator Score 28.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWS
1-70
SLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHEVFSAPAVPSGTGQTSAEL
70-140
EVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTV
140-210
TEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEV
210-280
SLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV
280-331
MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHEVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV
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