Tbio SPON2 Spondin-2

Protein Summary

Description

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Uniprot Accession IDs

• Q9BUD6
• D3DVN9
• Q4W5N4
• Q9ULW1

Gene Name

• SPON2

Ensembl ID

• ENST00000290902
• ENSP00000290902
• ENSG00000159674
• ENST00000431380
• ENSP00000394832
• ENST00000617421
• ENSP00000483599

Symbol

• DIL1
• DIL1
• DIL-1
• MINDIN
• M-SPONDIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.76
tissue sample	0.68
cell type or tissue	0.67
biological process	0.6
gene perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Spondin-2

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Spondin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.99   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.99   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0