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Tchem
MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

Protein Classes
Protein Summary
Description
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371945
  • ENSP00000361013
  • ENSG00000079277
  • ENST00000371946
  • ENSP00000361014
  • ENST00000428112
  • ENSP00000411135

Symbol
  • MNK1
  • MNK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.96
virus perturbation
0.88
disease perturbation
0.83
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.62   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 505   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.62   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 505   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4.3
17.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.3
17.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MAP kinase interacting serine/threonine kinase 1
710061
Mouse
MGI:894316
17346
Rat
RGD:1559603
500526
Dog
MAP kinase interacting serine/threonine kinase 1
VGNC:54216
482509
Horse
MAP kinase interacting serine/threonine kinase 1
VGNC:20204
100064521
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MAP kinase interacting serine/threonine kinase 1
Mouse
Rat
Dog
MAP kinase interacting serine/threonine kinase 1
Horse
MAP kinase interacting serine/threonine kinase 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUB5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (179)
Negative regulation of FGFR1 signaling (R-HSA-5654726)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of FGFR1 signaling
Reactome
Negative regulation of FGFR2 signaling
Reactome
Negative regulation of FGFR3 signaling
Reactome
Negative regulation of FGFR4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signal Transduction
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 1
Score: 0.981
Data Source: BioPlex,STRINGDB
EIF4E
Tchem
Novelty: 0.00072182
Score: 0.995
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.986
Data Source: STRINGDB
EIF4A1
Tchem
Novelty: 0.00269994
Score: 0.963
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.957
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.955
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.954
Data Source: STRINGDB
PLA2G4A
Tchem
Family: Enzyme
Novelty: 0.00158329
Score: 0.951
Data Source: STRINGDB
SPRY2
Tbio
Novelty: 0.00884945
Score: 0.941
Data Source: Reactome,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.938
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  63.62

PubMed score by year
PubTator Score  72.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer