MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1
Protein Summary
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
- ENST00000371945
- ENSP00000361013
- ENSG00000079277
- ENST00000371946
- ENSP00000361014
- ENST00000428112
- ENSP00000411135
- MNK1
- MNK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
molecular function | 0.96 | ||
virus perturbation | 0.88 | ||
disease perturbation | 0.83 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.72 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 505 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.72 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 505 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 91
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0