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Tdark
MYL10
Myosin regulatory light chain 10

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223167
  • ENSP00000223167
  • ENSG00000106436

Symbol
  • MYLC2PL
  • PLRLC
  • PLRLC
  • MYLC2PL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
small molecule perturbation
0.65
cell type or tissue
0.46
transcription factor
0.46
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
31.1
2
1
0
1.1
28.3
keratinocyte carcinoma
1
1
0
1.1
8.4
mathematical ability
1
1
1
4.9
eosinophil count
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
31.1
0
1.1
28.3
keratinocyte carcinoma
0
1.1
8.4
mathematical ability
1
4.9
eosinophil count
1
1.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 10
VGNC:4438
472470
Mouse
MGI:1891705
59310
Rat
RGD:1561258
501831
Dog
myosin light chain 10
VGNC:43542
608177
Cow
myosin light chain 10 [Source:HGNC Symbol;Acc:HGNC:29825]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 10
Mouse
Rat
Dog
myosin light chain 10
Cow
myosin light chain 10 [Source:HGNC Symbol;Acc:HGNC:29825]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BUA6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (88)
1 – 10 of 88
IQGAP1
Tbio
Family: Enzyme
Novelty: 0.00434481
p_int: 0.989102986
p_ni: 0.010897014
Score: 0.466
Data Source: BioPlex,STRINGDB
MYO19
Tbio
Novelty: 0.13070371
p_int: 0.978812579
p_ni: 0.021187421
Score: 0.627
Data Source: BioPlex,STRINGDB
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.992
Data Source: STRINGDB
MYH11
Tbio
Novelty: 0.00142474
Score: 0.976
Data Source: STRINGDB
TPM4
Tbio
Novelty: 0.00557194
Score: 0.958
Data Source: STRINGDB
TPM2
Tbio
Novelty: 0.00406572
Score: 0.958
Data Source: STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.954
Data Source: STRINGDB
TPM3
Tbio
Novelty: 0.00108151
Score: 0.953
Data Source: STRINGDB
ACTG2
Tbio
Novelty: 0.00304944
Score: 0.949
Data Source: STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.33

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer