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Tdark
LMF2
Lipase maturation factor 2

Protein Summary
Description
Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216080
  • ENSP00000216080
  • ENSG00000100258
  • ENST00000474879
  • ENSP00000424381

Symbol
  • TMEM112B
  • TMEM153
  • TMEM153
  • TMEM112B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cell type or tissue
0.72
transcription factor perturbation
0.68
kinase perturbation
0.6
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (48)
1 – 10 of 48
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.993371379
p_ni:  0.006628621
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.9891158
p_ni:  0.010884199
p_wrong:  1e-9
Data Source:  BioPlex
PNLDC1
Tbio
Family:  Enzyme
Novelty:  0.16308361
p_int:  0.985173721
p_ni:  0.014826274
p_wrong:  4e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.980994768
p_ni:  0.019005201
p_wrong:  3.2e-8
Data Source:  BioPlex
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.96659396
p_ni:  0.03340604
Score:  0.215
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.964338694
p_ni:  0.035661251
p_wrong:  5.5e-8
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.962944907
p_ni:  0.036517653
p_wrong:  0.000537441
Data Source:  BioPlex
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.960930336
p_ni:  0.039068991
p_wrong:  6.73e-7
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.952983624
p_ni:  0.047016238
p_wrong:  1.38e-7
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.934761246
p_ni:  0.064258574
p_wrong:  0.00098018
Data Source:  BioPlex
Pathways (4)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
99
mean reticulocyte volume
1
4
4
97.6
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
99
mean reticulocyte volume
4
97.6
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lipase maturation factor 2
720673
Mouse
MGI:2146015
105847
Rat
RGD:1306274
315218
Dog
lipase maturation factor 2
VGNC:42715
481188
Horse
lipase maturation factor 2
VGNC:19705
100056627
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lipase maturation factor 2
Mouse
Rat
Dog
lipase maturation factor 2
Horse
lipase maturation factor 2
Publication Statistics
PubMed Score 4.03
PubMed score by year
PubTator Score 1.00
PubTator score by year