Tbio THTPA Thiamine-triphosphatase

Protein Summary

Description

Hydrolase highly specific for thiamine triphosphate (ThTP). This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9BU02
• D3DS50
• G3V4J3
• ThTPase

Gene Name

• THTPA

Ensembl ID

• ENST00000288014
• ENSP00000288014
• ENSG00000259431
• ENST00000404535
• ENSP00000384580
• ENST00000554789
• ENSP00000450459
• ENST00000556015
• ENSP00000451835

Symbol

• THTP
• THTPASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
phenotype	0.67
tissue sample	0.61
transcription factor perturbation	0.54
cell line	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.44   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.44   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0