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Tbio
THTPA
Thiamine-triphosphatase

Protein Summary
Description
Hydrolase highly specific for thiamine triphosphate (ThTP). This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288014
  • ENSP00000288014
  • ENSG00000259431
  • ENST00000404535
  • ENSP00000384580
  • ENST00000554789
  • ENSP00000450459
  • ENST00000556015
  • ENSP00000451835

Symbol
  • THTP
  • THTPASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
phenotype
0.67
tissue sample
0.61
transcription factor perturbation
0.54
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
CLPX
Tbio
Family:  Enzyme
Novelty:  0.00254331
p_int:  0.996023378
p_ni:  0.003976622
Score:  0.243
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
p_int:  0.86885032
p_ni:  0.131149489
p_wrong:  1.92e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
p_int:  0.832773928
p_ni:  0.167224723
p_wrong:  0.000001348
Score:  0.54
Data Source:  BioPlex,STRINGDB
A6ZKI3
Tbio
Novelty:  0.20316911
p_int:  0.823804047
p_ni:  0.176194215
p_wrong:  0.000001738
Score:  0.237
Data Source:  BioPlex,STRINGDB
TPK1
Tbio
Family:  Kinase
Novelty:  0.00899463
Score:  0.976
Data Source:  STRINGDB
NTPCR
Tbio
Family:  Enzyme
Novelty:  0.0638186
Score:  0.9
Data Source:  STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
Score:  0.834
Data Source:  STRINGDB
USP5
Tchem
Family:  Enzyme
Novelty:  0.01478795
Score:  0.813
Data Source:  STRINGDB
UBA5
Tbio
Novelty:  0.05089296
Score:  0.803
Data Source:  STRINGDB
TLCD1
Tdark
Novelty:  0.76223034
Score:  0.77
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B1 (thiamin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B1 (thiamin) metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
62.8
resting heart rate
1
1
0
7.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
62.8
resting heart rate
0
7.4
17.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thiamine triphosphatase
VGNC:12471
745282
Mouse
MGI:2446078
105663
Rat
RGD:727917
305889
Dog
thiamine triphosphatase
VGNC:47359
490614
Horse
thiamine triphosphatase
VGNC:24094
100052214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thiamine triphosphatase
Mouse
Rat
Dog
thiamine triphosphatase
Horse
thiamine triphosphatase
Publication Statistics
PubMed Score 13.02
PubMed score by year
PubTator Score 26.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title