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Tbio
THTPA
Thiamine-triphosphatase

Protein Summary
Description
Hydrolase highly specific for thiamine triphosphate (ThTP). This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288014
  • ENSP00000288014
  • ENSG00000259431
  • ENST00000404535
  • ENSP00000384580
  • ENST00000554789
  • ENSP00000450459
  • ENST00000556015
  • ENSP00000451835

Symbol
  • THTP
  • THTPASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
phenotype
0.67
tissue sample
0.61
transcription factor perturbation
0.54
cell line
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thiamine triphosphatase
VGNC:12471
745282
Mouse
MGI:2446078
105663
Rat
RGD:727917
305889
Dog
thiamine triphosphatase
VGNC:47359
490614
Horse
thiamine triphosphatase
VGNC:24094
100052214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thiamine triphosphatase
Mouse
Rat
Dog
thiamine triphosphatase
Horse
thiamine triphosphatase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BU02-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B1 (thiamin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B1 (thiamin) metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (32)
1 – 10 of 32
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
p_int: 0.996023378
p_ni: 0.003976622
Score: 0.243
Data Source: BioPlex,STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
p_int: 0.86885032
p_ni: 0.131149489
p_wrong: 1.92e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
ITIH3
Tbio
Novelty: 0.04201144
p_int: 0.832773928
p_ni: 0.167224723
p_wrong: 0.000001348
Score: 0.54
Data Source: BioPlex,STRINGDB
RTL8C
Tbio
Novelty: 0.20316911
p_int: 0.823804047
p_ni: 0.176194215
p_wrong: 0.000001738
Score: 0.237
Data Source: BioPlex,STRINGDB
TPK1
Tbio
Family: Kinase
Novelty: 0.00899463
Score: 0.976
Data Source: STRINGDB
NTPCR
Tbio
Family: Enzyme
Novelty: 0.0638186
Score: 0.9
Data Source: STRINGDB
KDM5C
Tchem
Family: TF; Epigenetic
Novelty: 0.00701855
Score: 0.834
Data Source: STRINGDB
USP5
Tchem
Family: Enzyme
Novelty: 0.01478795
Score: 0.813
Data Source: STRINGDB
UBA5
Tbio
Novelty: 0.05089296
Score: 0.803
Data Source: STRINGDB
TLCD1
Tdark
Novelty: 0.76223034
Score: 0.77
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.02

PubMed score by year
PubTator Score  26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer