Tbio DHRS4 Dehydrogenase/reductase SDR family member 4

Protein Summary

Description

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Uniprot Accession IDs

• Q9BTZ2
• B2RB10
• B7WNS9
• D3YTB8
• E2QRL8
• O95162
• Q20CR0
• Q2LC19
• Q2LE81
• Q58IU4
• Q6E0Y1
• Q6UWU3
• Q71UQ6
• Q8TD03
• Q9H3N5
• Q9NV08

Gene Name

• DHRS4

Ensembl ID

• ENST00000313250
• ENSP00000326219
• ENSG00000157326
• ENST00000397074
• ENSP00000380264
• ENST00000397075
• ENSP00000380265
• ENST00000558263
• ENSP00000453367
• ENST00000558581
• ENSP00000452645
• ENST00000559632
• ENSP00000453983
• ENST00000643978
• ENSP00000493736
• ENSG00000284807
• ENST00000645602
• ENSP00000496349
• ENST00000645612
• ENSP00000494364
• ENST00000646997
• ENSP00000495877
• ENST00000647030
• ENSP00000496426
• ENST00000647154
• ENSP00000495868

Symbol

• SDR25C2
• CR
• NRDR
• PHCR
• PSCD
• SDR-SRL
• SDR25C1
• SDR25C2
• SCAD-SRL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.84
cellular component	0.78
protein domain	0.73
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.7   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.7   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0