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Tbio
DHRS4
Dehydrogenase/reductase SDR family member 4

Protein Summary
Description
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313250
  • ENSP00000326219
  • ENSG00000157326
  • ENST00000397074
  • ENSP00000380264
  • ENST00000397075
  • ENSP00000380265
  • ENST00000558263
  • ENSP00000453367
  • ENST00000558581
  • ENSP00000452645
  • ENST00000559632
  • ENSP00000453983
  • ENST00000643978
  • ENSP00000493736
  • ENSG00000284807
  • ENST00000645602
  • ENSP00000496349
  • ENST00000645612
  • ENSP00000494364
  • ENST00000646997
  • ENSP00000495877
  • ENST00000647030
  • ENSP00000496426
  • ENST00000647154
  • ENSP00000495868

Symbol
  • SDR25C2
  • CR
  • NRDR
  • PHCR
  • PSCD
  • SDR-SRL
  • SDR25C1
  • SDR25C2
  • SCAD-SRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.84
cellular component
0.78
protein domain
0.73
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
SUN2
Tbio
Novelty:  0.01387591
p_int:  0.999994094
p_ni:  0.000005906
Data Source:  BioPlex
ACADVL
Tbio
Family:  Enzyme
Novelty:  0.00383705
p_int:  0.999982784
p_ni:  0.000017216
Score:  0.283
Data Source:  BioPlex,STRINGDB
QPCT
Tchem
Family:  Enzyme
Novelty:  0.01687113
p_int:  0.999977766
p_ni:  0.000022234
Score:  0.195
Data Source:  BioPlex,STRINGDB
DHRS4L2
Tbio
Family:  Enzyme
Novelty:  0.03296542
p_int:  0.999871006
p_ni:  0.000128989
p_wrong:  5e-9
Score:  0.448
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.999843583
p_ni:  0.000156417
Score:  0.219
Data Source:  BioPlex,STRINGDB
TRIM43
Tdark
Novelty:  0.48246393
p_int:  0.999839799
p_ni:  0.000160201
Score:  0.173
Data Source:  BioPlex,STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.998469287
p_ni:  0.001530712
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
AIFM2
Tbio
Novelty:  0.02882373
p_int:  0.998185225
p_ni:  0.001814775
Data Source:  BioPlex
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
p_int:  0.997552368
p_ni:  0.002447628
p_wrong:  4e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.993775442
p_ni:  0.006198063
p_wrong:  0.000026494
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (9)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
55.2
liver disease biomarker
1
1
1
48.5
liver fat measurement
1
1
1
48.5
cognitive function measurement
1
1
1
17.8
triglyceride measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
55.2
liver disease biomarker
1
48.5
liver fat measurement
1
48.5
cognitive function measurement
1
17.8
triglyceride measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 4
452804
Macaque
dehydrogenase/reductase SDR family member 4 [Source:RefSeq peptide;Acc:NP_001181404]
Mouse
MGI:90169
28200
Rat
RGD:708482
266686
Dog
dehydrogenase/reductase 4
480254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 4
Macaque
dehydrogenase/reductase SDR family member 4 [Source:RefSeq peptide;Acc:NP_001181404]
Mouse
Rat
Dog
dehydrogenase/reductase 4
Publication Statistics
PubMed Score 35.63
PubMed score by year
PubTator Score 23.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title