You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FUCA2
Plasma alpha-L-fucosidase

Protein Summary
Description
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000002165
  • ENSP00000002165
  • ENSG00000001036

Symbol
  • dJ20N2.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.78
transcription factor perturbation
0.74
cell type or tissue
0.73
small molecule perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.64   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.64   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (233)
MAN2B2
Tbio
Family:  Enzyme
Novelty:  0.11499103
p_int:  0.999986613
p_ni:  0.000013386
p_wrong:  1e-9
Score:  0.314
Data Source:  BioPlex,STRINGDB
CLDN12
Tbio
Novelty:  0.04404633
p_int:  0.960104406
p_ni:  0.038794715
p_wrong:  0.00110088
Score:  0.622
Data Source:  BioPlex,STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.943832768
p_ni:  0.008363159
p_wrong:  0.047804073
Data Source:  BioPlex
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
p_int:  0.910302068
p_ni:  0.089697932
Score:  0.921
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.894459968
p_ni:  0.105540032
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.889520592
p_ni:  0.110479408
Data Source:  BioPlex
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.842554509
p_ni:  0.157438466
p_wrong:  0.000007025
Score:  0.169
Data Source:  BioPlex,STRINGDB
RAB21
Tbio
Family:  Enzyme
Novelty:  0.03221825
p_int:  0.792882909
p_ni:  0.207117041
p_wrong:  5.1e-8
Data Source:  BioPlex
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.984
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
44.2
skin aging measurement
1
1
1
29
1
1
0
1.1
21.5
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
44.2
skin aging measurement
1
29
0
1.1
21.5
self reported educational attainment
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-L-fucosidase 2
VGNC:14874
463039
Macaque
alpha-L-fucosidase 2
700611
Mouse
MGI:1914098
66848
Rat
RGD:1303053
292485
Dog
alpha-L-fucosidase 2
VGNC:53717
484016
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-L-fucosidase 2
Macaque
alpha-L-fucosidase 2
Mouse
Rat
Dog
alpha-L-fucosidase 2
Publication Statistics
PubMed Score 40.64
PubMed score by year
PubTator Score 20.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title