Tdark TMEM208 Transmembrane protein 208

Protein Summary

Description

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9BTX3
• Q05CT0
• Q96D25
• Q9NZZ7

Gene Name

• TMEM208

Ensembl ID

• ENST00000304800
• ENSP00000305892
• ENSG00000168701
• ENST00000562235
• ENSP00000457502

Symbol

• HSPC171

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
transcription factor binding site profile	0.82
virus perturbation	0.76
transcription factor perturbation	0.74
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.72   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0