Protein Summary
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
- ENST00000371429
- ENSP00000360483
- ENSG00000058804
- TMEM48
- NET3
- TMEM48
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.93 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.5 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.5 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (230)
AAAS
Novelty: 0.00830233
p_int: 0.998686988
p_ni: 0.001312843
p_wrong: 1.69e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
TMEM9
Novelty: 0.06916197
p_int: 0.998606141
p_ni: 0.001393064
p_wrong: 7.95e-7
Data Source: BioPlex
SCGB2A1
Novelty: 0.01902973
p_int: 0.991564411
p_ni: 0.008434871
p_wrong: 7.18e-7
Data Source: BioPlex
TSPAN5
Novelty: 0.08879443
p_int: 0.989885783
p_ni: 0.010114217
Score: 0.165
Data Source: BioPlex,STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.977416546
p_ni: 0.022583454
Data Source: BioPlex
IPPK
Family: Enzyme
Novelty: 0.02169701
p_int: 0.971914376
p_ni: 0.028085624
Data Source: BioPlex
CLCA2
Family: IC
Novelty: 0.0306541
p_int: 0.955753253
p_ni: 0.044246747
Score: 0.252
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (9)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 1 | 1 | 83.4 | |||||
thyroxine measurement | 1 | 1 | 1 | 81.1 | |||||
hormone measurement | 1 | 1 | 3 | 80.4 | |||||
balding measurement | 1 | 2 | 2 | 58.3 | |||||
nose morphology measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 83.4 | |||||
thyroxine measurement | 1 | 81.1 | |||||
hormone measurement | 3 | 80.4 | |||||
balding measurement | 2 | 58.3 | |||||
nose morphology measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NDC1 transmembrane nucleoporin | VGNC:11556 | 456867 | |||||
Mouse | MGI:1920037 | 72787 | ||||||
Rat | RGD:1560173 | 362557 | ||||||
Dog | NDC1 transmembrane nucleoporin | VGNC:43669 | 100684187 | |||||
Horse | NDC1 transmembrane nucleoporin | VGNC:20607 | 100050513 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NDC1 transmembrane nucleoporin | |||||
Mouse | ||||||
Rat | ||||||
Dog | NDC1 transmembrane nucleoporin | |||||
Horse | NDC1 transmembrane nucleoporin | |||||
Publication Statistics
PubMed Score 7.50
PubMed score by year
PubTator Score 11.96
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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