Protein Summary
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
- ENST00000371429
- ENSP00000360483
- ENSG00000058804
- TMEM48
- NET3
- TMEM48
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.93 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.5 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.5 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (230)
AAAS
Novelty: 0.00830233
p_int: 0.998686988
p_ni: 0.001312843
p_wrong: 1.69e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
TMEM9
Novelty: 0.06916197
p_int: 0.998606141
p_ni: 0.001393064
p_wrong: 7.95e-7
Data Source: BioPlex
SCGB2A1
Novelty: 0.01902973
p_int: 0.991564411
p_ni: 0.008434871
p_wrong: 7.18e-7
Data Source: BioPlex
TSPAN5
Novelty: 0.08879443
p_int: 0.989885783
p_ni: 0.010114217
Score: 0.165
Data Source: BioPlex,STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.977416546
p_ni: 0.022583454
Data Source: BioPlex
IPPK
Family: Enzyme
Novelty: 0.02169701
p_int: 0.971914376
p_ni: 0.028085624
Data Source: BioPlex
CLCA2
Family: IC
Novelty: 0.0306541
p_int: 0.955753253
p_ni: 0.044246747
Score: 0.252
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (9)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 1 | 1 | 83.4 | |||||
thyroxine measurement | 1 | 1 | 1 | 81.1 | |||||
hormone measurement | 1 | 1 | 3 | 80.4 | |||||
balding measurement | 1 | 2 | 2 | 58.3 | |||||
nose morphology measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 83.4 | |||||
thyroxine measurement | 1 | 81.1 | |||||
hormone measurement | 3 | 80.4 | |||||
balding measurement | 2 | 58.3 | |||||
nose morphology measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NDC1 transmembrane nucleoporin | VGNC:11556 | 456867 | |||||
Mouse | MGI:1920037 | 72787 | ||||||
Rat | RGD:1560173 | 362557 | ||||||
Dog | NDC1 transmembrane nucleoporin | VGNC:43669 | 100684187 | |||||
Horse | NDC1 transmembrane nucleoporin | VGNC:20607 | 100050513 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NDC1 transmembrane nucleoporin | |||||
Mouse | ||||||
Rat | ||||||
Dog | NDC1 transmembrane nucleoporin | |||||
Horse | NDC1 transmembrane nucleoporin | |||||
Publication Statistics
PubMed Score 7.50
PubMed score by year
PubTator Score 11.96
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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