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Tbio
NDC1
Nucleoporin NDC1

Protein Summary
Description
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
transcription factor perturbation
0.91
kinase perturbation
0.84
ligand (protein) perturbation
0.83
cellular component
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
JTB
Tbio
Novelty:  0.06646216
p_int:  0.998866557
p_ni:  0.001133442
p_wrong:  1e-9
Data Source:  BioPlex
AAAS
Tbio
Novelty:  0.00830233
p_int:  0.998686988
p_ni:  0.001312843
p_wrong:  1.69e-7
Score:  0.957
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.998606141
p_ni:  0.001393064
p_wrong:  7.95e-7
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.991564411
p_ni:  0.008434871
p_wrong:  7.18e-7
Data Source:  BioPlex
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.990321093
p_ni:  0.009678907
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.989885783
p_ni:  0.010114217
Score:  0.165
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.977416546
p_ni:  0.022583454
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.971914376
p_ni:  0.028085624
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.969105925
p_ni:  0.030894075
Data Source:  BioPlex
CLCA2
Tbio
Family:  IC
Novelty:  0.0306541
p_int:  0.955753253
p_ni:  0.044246747
Score:  0.252
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
1
1
83.4
thyroxine measurement
1
1
1
81.1
hormone measurement
1
1
3
80.4
balding measurement
1
2
2
58.3
nose morphology measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
83.4
thyroxine measurement
1
81.1
hormone measurement
3
80.4
balding measurement
2
58.3
nose morphology measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NDC1 transmembrane nucleoporin
VGNC:11556
456867
Mouse
MGI:1920037
72787
Rat
RGD:1560173
362557
Dog
NDC1 transmembrane nucleoporin
VGNC:43669
100684187
Horse
NDC1 transmembrane nucleoporin
VGNC:20607
100050513
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NDC1 transmembrane nucleoporin
Mouse
Rat
Dog
NDC1 transmembrane nucleoporin
Horse
NDC1 transmembrane nucleoporin
Publication Statistics
PubMed Score 7.50
PubMed score by year
PubTator Score 11.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title