Tbio NDC1 Nucleoporin NDC1

Protein Summary

Description

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

Uniprot Accession IDs

• Q9BTX1
• B4DHA3
• B4DQQ5
• G3XA81
• Q8NB76
• Q9H9T6
• Q9NSG3
• Q9NSG4
• Q9NVZ7
• hNDC1

Gene Name

• NDC1

Ensembl ID

• ENST00000371429
• ENSP00000360483
• ENSG00000058804

Symbol

• TMEM48
• NET3
• TMEM48

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
transcription factor perturbation	0.91
kinase perturbation	0.84
ligand (protein) perturbation	0.83
cellular component	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.68   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.68   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0