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Tbio
PI4K2A
Phosphatidylinositol 4-kinase type 2-alpha

Protein Summary
Description
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370631
  • ENSP00000359665
  • ENSG00000155252

Symbol
  • PI4KII
  • PIK42A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor perturbation
0.84
disease perturbation
0.83
cellular component
0.78
kinase perturbation
0.76


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 alpha
VGNC:12425
450656
Mouse
MGI:1934031
84095
Rat
RGD:620485
114554
Dog
phosphatidylinositol 4-kinase type 2 alpha
486824
Horse
phosphatidylinositol 4-kinase type 2 alpha
100070680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 alpha
Mouse
Rat
Dog
phosphatidylinositol 4-kinase type 2 alpha
Horse
phosphatidylinositol 4-kinase type 2 alpha
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BTU6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (71)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Protein-Protein Interactions (172)
1 – 10 of 172
GABARAPL1
Tbio
Novelty: 0.00212657
p_int: 0.999997544
p_ni: 5.7e-8
p_wrong: 0.000002399
Score: 0.162
Data Source: BioPlex,STRINGDB
GABARAP
Tbio
Novelty: 0.00444901
p_int: 0.999994995
p_ni: 0.000004921
p_wrong: 8.4e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.999975832
p_ni: 0.000024164
p_wrong: 4e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.999849578
p_ni: 0.000150313
p_wrong: 1.09e-7
Data Source: BioPlex
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.999826597
p_ni: 0.000173398
p_wrong: 5e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.999363506
p_ni: 0.000636493
p_wrong: 1e-9
Data Source: BioPlex
PVR
Tbio
Novelty: 0.00215811
p_int: 0.999300563
p_ni: 0.00065699
p_wrong: 0.000042446
Score: 0.157
Data Source: BioPlex,STRINGDB
IRGC
Tbio
Family: Enzyme
Novelty: 0.10743948
p_int: 0.999255615
p_ni: 0.00069217
p_wrong: 0.000052214
Score: 0.177
Data Source: BioPlex,STRINGDB
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.998959619
p_ni: 0.000958677
p_wrong: 0.000081704
Data Source: BioPlex
ANKRD13A
Tbio
Novelty: 0.61940334
p_int: 0.998672649
p_ni: 0.001327351
Data Source: BioPlex
Publication Statistics
PubMed Score  26.68

PubMed score by year
PubTator Score  14.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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