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Tbio
LRRC1
Leucine-rich repeat-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370888
  • ENSP00000359925
  • ENSG00000137269
  • ENST00000487251
  • ENSP00000435217

Symbol
  • LANO
  • LANO
  • dJ523E19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.86
virus perturbation
0.85
transcription factor
0.64
tissue sample
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.997624908
p_ni:  0.002375092
Score:  0.348
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.995097283
p_ni:  0.004902711
p_wrong:  6e-9
Score:  0.348
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.980194795
p_ni:  0.019805205
Data Source:  BioPlex
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.960901905
p_ni:  0.039098095
Data Source:  BioPlex
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.954661635
p_ni:  0.045338293
p_wrong:  7.2e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.933820811
p_ni:  0.066178838
p_wrong:  3.5e-7
Score:  0.232
Data Source:  BioPlex,STRINGDB
KCNJ6
Tchem
Family:  IC
Novelty:  0.00330353
p_int:  0.899910039
p_ni:  0.100089961
Score:  0.188
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.89407466
p_ni:  0.10592534
Data Source:  BioPlex
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.887721339
p_ni:  0.112278661
Data Source:  BioPlex
STX11
Tbio
Novelty:  0.01670743
p_int:  0.858840233
p_ni:  0.141159767
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
24.3
1
1
1
11.1
waist-hip ratio
1
1
1
8.8
hip circumference
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
24.3
1
11.1
waist-hip ratio
1
8.8
hip circumference
1
2.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 1
VGNC:12650
462779
Macaque
leucine rich repeat containing 1
710867
Mouse
MGI:2442313
214345
Rat
RGD:1549773
367113
Dog
leucine rich repeat containing 1
VGNC:42783
481847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 1
Macaque
leucine rich repeat containing 1
Mouse
Rat
Dog
leucine rich repeat containing 1
Publication Statistics
PubMed Score 13.39
PubMed score by year
PubTator Score 6.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title