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Tdark
MED10
Mediator of RNA polymerase II transcription subunit 10

Protein Classes
Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255764
  • ENSP00000255764
  • ENSG00000133398

Symbol
  • L6
  • NUT2
  • TRG20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
kinase perturbation
0.96
transcription factor perturbation
0.74
histone modification site profile
0.69
tissue sample
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 10
VGNC:4084
743557
Macaque
mediator complex subunit 10
694872
Mouse
MGI:106331
28077
Rat
RGD:1310128
290939
Dog
mediator complex subunit 10
VGNC:43118
607911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 10
Macaque
mediator complex subunit 10
Mouse
Rat
Dog
mediator complex subunit 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BTT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Protein-Protein Interactions (135)
1 – 10 of 135
MED26
Tbio
Family: Enzyme
Novelty: 0.05663538
p_int: 0.99999949
p_ni: 5.1e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
MED12L
Tdark
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999999464
p_ni: 5.34e-7
p_wrong: 2e-9
Score: 0.679
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999436
p_ni: 5.62e-7
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
MED24
Tbio
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999999142
p_ni: 8.59e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
MED13L
Tbio
Family: Enzyme
Novelty: 0.03766796
p_int: 0.999998804
p_ni: 0.000001196
Score: 0.995
Data Source: BioPlex,STRINGDB
MED14
Tbio
Family: Enzyme
Novelty: 0.01741917
p_int: 0.999998697
p_ni: 0.000001303
Score: 0.999
Data Source: BioPlex,STRINGDB
MED27
Tbio
Family: Enzyme
Novelty: 0.02511389
p_int: 0.999998594
p_ni: 0.000001406
Score: 0.996
Data Source: BioPlex,STRINGDB
MED8
Tbio
Family: Enzyme
Novelty: 0.06648307
p_int: 0.999998553
p_ni: 0.000001447
Score: 0.999
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.99999837
p_ni: 0.000001619
p_wrong: 1.2e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
p_int: 0.999997887
p_ni: 0.000002113
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.36

PubMed score by year
PubTator Score  18.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer