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Tbio
ANP32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

Protein Summary
Description
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436748
  • ENSP00000393718
  • ENSG00000143401
  • ENST00000583931
  • ENSP00000463154
  • ENST00000616917
  • ENSP00000481415

Symbol
  • LANPL
  • LANP-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.92
small molecule perturbation
0.9
cellular component
0.75
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999571624
p_ni:  0.000428376
Score:  0.923
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.998405261
p_ni:  0.001594739
Score:  0.202
Data Source:  BioPlex,STRINGDB
PAPPA
Tbio
Novelty:  0.00062817
Score:  0.99
Data Source:  STRINGDB
EP400
Tbio
Novelty:  0.02013098
Score:  0.956
Data Source:  STRINGDB
ACTL6A
Tbio
Novelty:  0.01892162
Score:  0.943
Data Source:  STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.943
Data Source:  STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
Score:  0.943
Data Source:  STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
Score:  0.942
Data Source:  STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
Score:  0.937
Data Source:  STRINGDB
BRD8
Tbio
Family:  Epigenetic
Novelty:  0.09769287
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1
89.6
glomerular filtration rate
4
4
4
87.4
circadian rhythm
5
3
3
1.1
83.6
red blood cell distribution width
2
2
2
68.8
leukocyte count
1
1
1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
89.6
glomerular filtration rate
4
87.4
circadian rhythm
3
1.1
83.6
red blood cell distribution width
2
68.8
leukocyte count
1
67.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
acidic nuclear phosphoprotein 32 family member E
706251
Mouse
MGI:1913721
66471
Rat
RGD:1310611
361999
Dog
acidic nuclear phosphoprotein 32 family member E
VGNC:37934
100855771
Horse
acidic nuclear phosphoprotein 32 family member E
VGNC:15356
100054493
Species
Name
OMA
EggNOG
Inparanoid
Macaque
acidic nuclear phosphoprotein 32 family member E
Mouse
Rat
Dog
acidic nuclear phosphoprotein 32 family member E
Horse
acidic nuclear phosphoprotein 32 family member E
Publication Statistics
PubMed Score 17.23
PubMed score by year
PubTator Score 7.55
PubTator score by year
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Related Publications
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PMID
Year
Title