You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAAP24
Fanconi anemia core complex-associated protein 24

Protein Summary
Description
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000588258
  • ENSP00000466121
  • ENSG00000131944
  • ENST00000590281
  • ENSP00000468475

Symbol
  • C19orf40
  • C19orf40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
FANCM
Tbio
Novelty:  0.01122278
p_int:  0.999998066
p_ni:  0.00000191
p_wrong:  2.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.999
Data Source:  Reactome,STRINGDB
FANCA
Tbio
Novelty:  0.00324947
Score:  0.999
Data Source:  STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
Score:  0.999
Data Source:  STRINGDB
CENPX
Tbio
Novelty:  0.08344454
Score:  0.999
Data Source:  Reactome,STRINGDB
FAAP20
Tbio
Novelty:  0.15112645
Score:  0.996
Data Source:  STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
Score:  0.992
Data Source:  STRINGDB
FANCB
Tbio
Novelty:  0.00268111
Score:  0.991
Data Source:  STRINGDB
FANCG
Tbio
Novelty:  0.00908902
Score:  0.99
Data Source:  STRINGDB
FANCI
Tbio
Novelty:  0.01223788
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
13
99.2
glomerular filtration rate
3
3
4
96.7
alkaline phosphatase measurement
2
2
1
10.4
92.2
creatinine measurement
2
3
3
91.7
4
3
0
1.2
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
13
99.2
glomerular filtration rate
4
96.7
alkaline phosphatase measurement
1
10.4
92.2
creatinine measurement
3
91.7
0
1.2
90.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 24
VGNC:2554
455926
Macaque
Fanconi anemia core complex associated protein 24
716564
Mouse
MGI:2142208
101831
Rat
RGD:1564719
502320
Dog
Fanconi anemia core complex associated protein 24
VGNC:40557
476496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 24
Macaque
Fanconi anemia core complex associated protein 24
Mouse
Rat
Dog
Fanconi anemia core complex associated protein 24
Publication Statistics
PubMed Score 9.92
PubMed score by year
PubTator Score 7.06
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title