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Tbio
FAAP24
Fanconi anemia core complex-associated protein 24

Protein Summary
Description
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000588258
  • ENSP00000466121
  • ENSG00000131944
  • ENST00000590281
  • ENSP00000468475

Symbol
  • C19orf40
  • C19orf40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (125)
1 – 10 of 125
FANCM
Tbio
Novelty: 0.01500746
p_int: 0.999998066
p_ni: 0.00000191
p_wrong: 2.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CENPS
Tbio
Novelty: 0.00836898
Score: 0.999
Data Source: Reactome,STRINGDB
FANCA
Tbio
Novelty: 0.00397648
Score: 0.999
Data Source: STRINGDB
FAAP100
Tdark
Novelty: 0.7968976
Score: 0.999
Data Source: STRINGDB
CENPX
Tbio
Novelty: 0.12859767
Score: 0.999
Data Source: Reactome,STRINGDB
FAAP20
Tbio
Novelty: 0.21116139
Score: 0.996
Data Source: STRINGDB
FANCL
Tbio
Family: Enzyme
Novelty: 0.00313016
Score: 0.992
Data Source: STRINGDB
FANCB
Tbio
Novelty: 0.01506796
Score: 0.991
Data Source: STRINGDB
FANCG
Tbio
Novelty: 0.00411649
Score: 0.99
Data Source: STRINGDB
FANCI
Tbio
Novelty: 0.01680302
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.79

PubMed score by year
PubTator Score  7.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer