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Tbio
URM1
Ubiquitin-related modifier 1

Protein Summary
Description
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372850
  • ENSP00000361941
  • ENSG00000167118
  • ENST00000372853
  • ENSP00000361944
  • ENST00000452446
  • ENSP00000412922

Symbol
  • C9orf74
  • C9orf74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
disease perturbation
0.79
transcription factor perturbation
0.74
co-expressed gene
0.69
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.54   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.54   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
CTU1
Tbio
Novelty:  0.04670058
Score:  0.998
Data Source:  Reactome,STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
Score:  0.996
Data Source:  STRINGDB
CTU2
Tdark
Novelty:  0.00936441
Score:  0.993
Data Source:  Reactome,STRINGDB
UFM1
Tbio
Novelty:  0.0215914
Score:  0.896
Data Source:  STRINGDB
USP5
Tchem
Family:  Enzyme
Novelty:  0.01478795
Score:  0.864
Data Source:  STRINGDB
PRDX2
Tbio
Novelty:  0.00189751
Score:  0.851
Data Source:  STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.851
Data Source:  STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.845
Data Source:  STRINGDB
ALKBH8
Tbio
Novelty:  0.02797162
Score:  0.836
Data Source:  STRINGDB
MCM5
Tbio
Novelty:  0.00716583
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
1
3
51.4
pulse pressure measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
51.4
pulse pressure measurement
1
9.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin related modifier 1
VGNC:14401
464905
Macaque
ubiquitin related modifier 1
722618
Mouse
MGI:1915455
68205
Rat
RGD:1306599
311840
Dog
ubiquitin related modifier 1
VGNC:48167
608549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin related modifier 1
Macaque
ubiquitin related modifier 1
Mouse
Rat
Dog
ubiquitin related modifier 1
Publication Statistics
PubMed Score 47.54
PubMed score by year
PubTator Score 7.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title