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Tbio
RAMAC
RNA guanine-N7 methyltransferase activating subunit

Protein Summary
Description
Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304191
  • ENSP00000307181
  • ENSG00000169612

Symbol
  • C15orf18
  • FAM103A1
  • RAMMET
  • RAM
  • RAMMET
  • C15orf18
  • FAM103A1
  • HsT19360
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.94
kinase perturbation
0.76
cell type or tissue
0.7
disease perturbation
0.68
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
50.6
BMI-adjusted hip circumference
1
1
1
49.5
hip circumference
1
1
1
29
1
1
0
1.1
26.6
basophil count
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
50.6
BMI-adjusted hip circumference
1
49.5
hip circumference
1
29
0
1.1
26.6
basophil count
1
8.9
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BTL3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (25)
1 – 10 of 25
RNMT
Tbio
Family:  Enzyme
Novelty:  0.00880207
p_int:  0.999806412
p_ni:  0.000193588
Score:  0.998
Data Source:  BioPlex,STRINGDB
NCBP2
Tbio
Novelty:  0.01426734
Score:  0.918
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.915
Data Source:  STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.91
Data Source:  STRINGDB
EIF4E2
Tbio
Novelty:  0.0490219
Score:  0.902
Data Source:  STRINGDB
AGO2
Tbio
Novelty:  0.00057003
Score:  0.9
Data Source:  STRINGDB
NCBP3
Tbio
Novelty:  0.07581882
Score:  0.9
Data Source:  STRINGDB
EIF4E1B
Tdark
Novelty:  0.28023341
Score:  0.726
Data Source:  STRINGDB
EIF4E3
Tbio
Novelty:  0.07055626
Score:  0.725
Data Source:  STRINGDB
FMR1
Tbio
Family:  Epigenetic
Novelty:  0.00032203
Score:  0.724
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.68

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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