Tbio RAMAC RNA guanine-N7 methyltransferase activating subunit

Protein Summary

Description

Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306).

Uniprot Accession IDs

• Q9BTL3
• Q2M1J8

Gene Name

• RAMAC

Ensembl ID

• ENST00000304191
• ENSP00000307181
• ENSG00000169612

Symbol

• C15orf18
• FAM103A1
• RAMMET
• RAM
• RAMMET
• C15orf18
• FAM103A1
• HsT19360

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.94
kinase perturbation	0.76
cell type or tissue	0.7
disease perturbation	0.68
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0