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Tbio
PAGR1
PAXIP1-associated glutamate-rich protein 1

Protein Summary
Description
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320330
  • ENSP00000326519
  • ENSG00000280789

Symbol
  • C16orf53
  • PA1
  • GAS
  • PA1
  • C16orf53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
virus perturbation
0.76
tissue sample
0.74
kinase perturbation
0.71
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (35)
1 – 10 of 35
PAXIP1
Tbio
Novelty:  0.01728724
Score:  0.981
Data Source:  STRINGDB
DPY30
Tbio
Novelty:  0.03098629
Score:  0.977
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.976
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.975
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.974
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.97
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.968
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.946
Data Source:  STRINGDB
ASPHD1
Tdark
Family:  Enzyme
Novelty:  0.97195692
Score:  0.744
Data Source:  STRINGDB
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
Score:  0.696
Data Source:  STRINGDB
Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
82
mean platelet volume
3
2
3
72.9
alcohol consumption measurement
3
1
3
64
C-reactive protein measurement
1
1
1
52.4
bitter alcoholic beverage consumption measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
82
mean platelet volume
3
72.9
alcohol consumption measurement
3
64
C-reactive protein measurement
1
52.4
bitter alcoholic beverage consumption measurement
1
48.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAXIP1 associated glutamate rich protein 1
VGNC:9096
738201
Mouse
MGI:1914528
67278
Rat
RGD:1305592
293500
Dog
PAXIP1 associated glutamate rich protein 1
VGNC:54053
489939
Horse
PAXIP1 associated glutamate rich protein 1
VGNC:51215
100063953
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAXIP1 associated glutamate rich protein 1
Mouse
Rat
Dog
PAXIP1 associated glutamate rich protein 1
Horse
PAXIP1 associated glutamate rich protein 1
Publication Statistics
PubMed Score 3.08
PubMed score by year
PubTator Score 257.88
PubTator score by year