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Tdark
DCTN5
Dynactin subunit 5

Protein Summary
Description
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300087
  • ENSP00000300087
  • ENSG00000166847
  • ENST00000563998
  • ENSP00000454691
  • ENST00000568272
  • ENSP00000455685
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
microRNA
0.9
disease perturbation
0.87
transcription factor binding site profile
0.82
cell type or tissue
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (225)
1 – 10 of 225
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.999999165
p_ni: 8.35e-7
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty: 0.30624393
p_int: 0.999994706
p_ni: 0.000005292
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN4
Tbio
Novelty: 0.10319227
p_int: 0.999993891
p_ni: 0.000006109
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty: 0.14551388
p_int: 0.999947901
p_ni: 0.000052099
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty: 0.10014723
p_int: 0.999943045
p_ni: 0.000056926
p_wrong: 2.9e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.999922827
p_ni: 0.000077162
p_wrong: 1.1e-8
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
PDGFD
Tbio
Novelty: 0.00799996
p_int: 0.999833151
p_ni: 0.000165805
p_wrong: 0.000001044
Score: 0.696
Data Source: BioPlex,STRINGDB
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.999696275
p_ni: 0.000303638
p_wrong: 8.7e-8
Score: 0.377
Data Source: BioPlex,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
p_int: 0.999413
p_ni: 0.000587
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.99881607
p_ni: 0.001183919
p_wrong: 1.2e-8
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  4.90

PubMed score by year
PubTator Score  3.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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