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Tbio
DIDO1
Death-inducer obliterator 1

Protein Summary
Description
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266070
  • ENSP00000266070
  • ENSG00000101191
  • ENST00000354665
  • ENSP00000346692
  • ENST00000370366
  • ENSP00000359391
  • ENST00000370368
  • ENSP00000359394
  • ENST00000370371
  • ENSP00000359397
  • ENST00000395340
  • ENSP00000378749
  • ENST00000395343
  • ENSP00000378752

Symbol
  • C20orf158
  • DATF1
  • KIAA0333
  • BYE1
  • DIO1
  • DATF1
  • DIDO2
  • DIDO3
  • DIO-1
  • DATF-1
  • C20orf158
  • dJ885L7.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.98
transcription factor perturbation
0.98
protein domain
0.97
drug perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.32   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.32   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
49.3
age at menopause
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
49.3
age at menopause
1
38.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death inducer-obliterator 1
100612452
Macaque
death inducer-obliterator 1
698313
Mouse
MGI:1344352
23856
Rat
RGD:1311173
362286
Dog
death inducer-obliterator 1
VGNC:54296
485965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death inducer-obliterator 1
Macaque
death inducer-obliterator 1
Mouse
Rat
Dog
death inducer-obliterator 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BTC0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (133)
1 – 10 of 133
SFPQ
Tbio
Novelty: 0.01207637
p_int: 0.999931434
p_ni: 0.000068566
Score: 0.421
Data Source: BioPlex,STRINGDB
FBXO46
Tdark
Novelty: 1.45550259
p_int: 0.999923985
p_ni: 0.000076015
Data Source: BioPlex
HCFC1
Tbio
Novelty: 0.00440762
p_int: 0.999301829
p_ni: 0.000698172
Score: 0.241
Data Source: BioPlex,STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.999145434
p_ni: 0.00082948
p_wrong: 0.000025086
Score: 0.158
Data Source: BioPlex,STRINGDB
PIN1
Tchem
Family: Enzyme
Novelty: 0.00957198
p_int: 0.997548439
p_ni: 0.002451527
p_wrong: 3.4e-8
Score: 0.512
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.991421217
p_ni: 0.008578784
Score: 0.279
Data Source: BioPlex,STRINGDB
CAPN13
Tdark
Novelty: 0.27206398
p_int: 0.990956636
p_ni: 0.009042939
p_wrong: 4.24e-7
Score: 0.21
Data Source: BioPlex,STRINGDB
OGT
Tchem
Family: Enzyme
Novelty: 0.00290822
p_int: 0.981408321
p_ni: 0.018591679
Score: 0.262
Data Source: BioPlex,STRINGDB
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
p_int: 0.973113266
p_ni: 0.026886734
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.96166
p_ni: 0.01035157
p_wrong: 0.027988429
Score: 0.165
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.32

PubMed score by year
PubTator Score  8.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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