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Tbio
WAC
WW domain-containing adapter protein with coiled-coil

Protein Summary
Description
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). The protein en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347934
  • ENSP00000311106
  • ENSG00000095787
  • ENST00000354911
  • ENSP00000346986
  • ENST00000375664
  • ENSP00000364816
  • ENST00000439676
  • ENSP00000415727

Symbol
  • KIAA1844
  • Wwp4
  • DESSH
  • BM-016
  • PRO1741
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.96
disease perturbation
0.93
biological process
0.89
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
37.3
mean reticulocyte volume
1
1
1
4.5
diastolic blood pressure
1
1
1
3.4
mean corpuscular volume
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
37.3
mean reticulocyte volume
1
4.5
diastolic blood pressure
1
3.4
mean corpuscular volume
1
1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW domain containing adaptor with coiled-coil
VGNC:5880
450378
Macaque
WW domain containing adaptor with coiled-coil
715828
Mouse
MGI:2387357
225131
Rat
RGD:1562407
307029
Horse
WW domain containing adaptor with coiled-coil
VGNC:24962
100064150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW domain containing adaptor with coiled-coil
Macaque
WW domain containing adaptor with coiled-coil
Mouse
Rat
Horse
WW domain containing adaptor with coiled-coil
Pathways (4)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (119)
1 – 10 of 119
RNF20
Tbio
Family: Enzyme
Novelty: 0.01238827
p_int: 0.999999979
p_ni: 1.7e-8
p_wrong: 4e-9
Score: 0.975
Data Source: BioPlex,STRINGDB
RNF40
Tbio
Family: Enzyme
Novelty: 0.07038528
p_int: 0.99999978
p_ni: 2.2e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.984969731
p_ni: 0.014759908
p_wrong: 0.000270361
Score: 0.167
Data Source: BioPlex,STRINGDB
UBE2A
Tbio
Novelty: 0.01670792
Score: 0.933
Data Source: STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
Score: 0.922
Data Source: STRINGDB
WDR61
Tbio
Novelty: 0.01405991
Score: 0.921
Data Source: STRINGDB
LEO1
Tbio
Family: Enzyme
Novelty: 0.00851903
Score: 0.92
Data Source: STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.917
Data Source: STRINGDB
CDC73
Tbio
Novelty: 0.00362973
Score: 0.916
Data Source: STRINGDB
UBE2B
Tbio
Novelty: 0.01578275
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.63

PubMed score by year
PubTator Score  4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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