You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NDFIP1
NEDD4 family-interacting protein 1

Protein Summary
Description
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become ef ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253814
  • ENSP00000253814
  • ENSG00000131507

Symbol
  • N4WBP5
  • N4WBP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.97
disease perturbation
0.93
transcription factor perturbation
0.88
transcription factor binding site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.995288793
p_ni:  0.004711207
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.994464165
p_ni:  0.005535835
Score:  0.192
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.990633181
p_ni:  0.009366819
Data Source:  BioPlex
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.985409939
p_ni:  0.014590061
Data Source:  BioPlex
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.975076593
p_ni:  0.024923407
Score:  0.196
Data Source:  BioPlex,STRINGDB
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.974716905
p_ni:  0.023582165
p_wrong:  0.00170093
Data Source:  BioPlex
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.971287653
p_ni:  0.028712347
Data Source:  BioPlex
C16orf58
Tdark
Novelty:  0.34461652
p_int:  0.964789234
p_ni:  0.035210766
Data Source:  BioPlex
IFNGR1
Tbio
Novelty:  0.00417244
p_int:  0.963144824
p_ni:  0.036855176
Score:  0.518
Data Source:  BioPlex,STRINGDB
PTGFR
Tclin
Family:  GPCR
Novelty:  0.00560908
p_int:  0.955440566
p_ni:  0.044556573
p_wrong:  0.000002861
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
97.4
platelet count
4
4
4
94.5
platelet crit
2
2
2
93.8
eosinophil percentage of leukocytes
2
2
2
92.3
neutrophil count
3
3
3
91
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
97.4
platelet count
4
94.5
platelet crit
2
93.8
eosinophil percentage of leukocytes
2
92.3
neutrophil count
3
91
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Nedd4 family interacting protein 1
VGNC:4094
462156
Macaque
Nedd4 family interacting protein 1
705716
Mouse
MGI:1929601
65113
Rat
RGD:1310053
291609
Dog
Nedd4 family interacting protein 1
VGNC:43673
478044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Nedd4 family interacting protein 1
Macaque
Nedd4 family interacting protein 1
Mouse
Rat
Dog
Nedd4 family interacting protein 1
Publication Statistics
PubMed Score 32.11
PubMed score by year
PubTator Score 13.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title