NDFIP1
NEDD4 family-interacting protein 1
Protein Summary
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become ef ...more
- ENST00000253814
- ENSP00000253814
- ENSG00000131507
- N4WBP5
- N4WBP5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
biological process | 0.97 | ||
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.11 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.11 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (63)
SLC1A1
Family: Transporter
Novelty: 0.00218479
p_int: 0.995288793
p_ni: 0.004711207
Data Source: BioPlex
TSPAN3
Novelty: 0.06362133
p_int: 0.994464165
p_ni: 0.005535835
Score: 0.192
Data Source: BioPlex,STRINGDB
TMEM231
Novelty: 0.17100188
p_int: 0.975076593
p_ni: 0.024923407
Score: 0.196
Data Source: BioPlex,STRINGDB
FCER1A
Novelty: 0.00362182
p_int: 0.974716905
p_ni: 0.023582165
p_wrong: 0.00170093
Data Source: BioPlex
IFNGR1
Novelty: 0.00417244
p_int: 0.963144824
p_ni: 0.036855176
Score: 0.518
Data Source: BioPlex,STRINGDB
PTGFR
Family: GPCR
Novelty: 0.00560908
p_int: 0.955440566
p_ni: 0.044556573
p_wrong: 0.000002861
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (1)
Components (10)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 4 | 4 | 97.4 | |||||
platelet count | 4 | 4 | 4 | 94.5 | |||||
platelet crit | 2 | 2 | 2 | 93.8 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 92.3 | |||||
neutrophil count | 3 | 3 | 3 | 91 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 97.4 | |||||
platelet count | 4 | 94.5 | |||||
platelet crit | 2 | 93.8 | |||||
eosinophil percentage of leukocytes | 2 | 92.3 | |||||
neutrophil count | 3 | 91 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Nedd4 family interacting protein 1 | VGNC:4094 | 462156 | |||||
Macaque | Nedd4 family interacting protein 1 | 705716 | ||||||
Mouse | MGI:1929601 | 65113 | ||||||
Rat | RGD:1310053 | 291609 | ||||||
Dog | Nedd4 family interacting protein 1 | VGNC:43673 | 478044 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Nedd4 family interacting protein 1 | |||||
Macaque | Nedd4 family interacting protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Nedd4 family interacting protein 1 | |||||
Publication Statistics
PubMed Score 32.11
PubMed score by year
PubTator Score 13.17
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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