Tbio THAP7 THAP domain-containing protein 7

Protein Summary

Description

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Uniprot Accession IDs

• Q9BT49
• B2RD97
• D3DX40

Gene Name

• THAP7

Ensembl ID

• ENST00000215742
• ENSP00000215742
• ENSG00000184436
• ENST00000399133
• ENSP00000382084

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.71
cell line	0.61
tissue sample	0.61
cell type or tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0