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Tdark
POLR3GL
DNA-directed RNA polymerase III subunit RPC7-like

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369314
  • ENSP00000358320
  • ENSG00000121851

Symbol
  • RPC32HOM
  • flj32422
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
transcription factor binding site profile
0.77
virus perturbation
0.72
kinase perturbation
0.66
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
3
3
90.6
myeloid white cell count
1
1
1
68.8
granulocyte count
1
1
1
46.9
high density lipoprotein cholesterol measurement
1
1
1
40.7
apolipoprotein A 1 measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
90.6
myeloid white cell count
1
68.8
granulocyte count
1
46.9
high density lipoprotein cholesterol measurement
1
40.7
apolipoprotein A 1 measurement
1
38.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase III subunit G like
698563
Mouse
MGI:1917120
69870
Rat
RGD:1582857
690254
Dog
RNA polymerase III subunit G like
608346
Horse
RNA polymerase III subunit G like
100146677
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase III subunit G like
Mouse
Rat
Dog
RNA polymerase III subunit G like
Horse
RNA polymerase III subunit G like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BT43-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (116)
1 – 10 of 116
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
p_int:  0.999999982
p_ni:  1.7e-8
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.999999897
p_ni:  1.03e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
p_int:  0.999999854
p_ni:  1.45e-7
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
p_int:  0.999999793
p_ni:  2.07e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.999999785
p_ni:  2.15e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
CRCP
Tbio
Family:  Enzyme
Novelty:  0.01111812
p_int:  0.999998409
p_ni:  0.000001568
p_wrong:  2.3e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.999991052
p_ni:  0.000004955
p_wrong:  0.000003993
Score:  0.982
Data Source:  BioPlex,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.999975223
p_ni:  0.000024777
Score:  0.98
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999643907
p_ni:  0.000356093
Score:  0.982
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.16

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer