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Tbio
HAUS8
HAUS augmin-like complex subunit 8

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253669
  • ENSP00000253669
  • ENSG00000131351
  • ENST00000448593
  • ENSP00000395298
  • ENST00000593360
  • ENSP00000470829

Symbol
  • HICE1
  • DGT4
  • HICE1
  • NY-SAR-48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.71
tissue sample
0.65
histone modification site profile
0.61
cellular component
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.99999994
p_ni:  6e-8
Score:  0.94
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.997171468
p_ni:  0.002828532
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.959247473
p_ni:  0.04067327
p_wrong:  0.000079257
Data Source:  BioPlex
BNIP1
Tbio
Novelty:  0.04601895
p_int:  0.952763174
p_ni:  0.047236826
Score:  0.183
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.914248493
p_ni:  0.085751506
p_wrong:  1e-9
Data Source:  BioPlex
PRELID2
Tdark
Novelty:  0.38276284
p_int:  0.854947662
p_ni:  0.144940329
p_wrong:  0.000112008
Data Source:  BioPlex
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.822657366
p_ni:  0.177342634
Data Source:  BioPlex
MTMR12
Tbio
Novelty:  0.11861954
p_int:  0.814777904
p_ni:  0.185221988
p_wrong:  1.07e-7
Score:  0.622
Data Source:  BioPlex,STRINGDB
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.798076624
p_ni:  0.201923303
p_wrong:  7.3e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
HYLS1
Tbio
Novelty:  0.03257577
p_int:  0.766574752
p_ni:  0.23342456
p_wrong:  6.88e-7
Score:  0.269
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
6
96.7
mean corpuscular volume
1
3
3
96.7
HbA1c measurement
6
13
13
96.2
reticulocyte count
6
4
10
93.6
mean platelet volume
3
2
3
93
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
96.7
mean corpuscular volume
3
96.7
HbA1c measurement
13
96.2
reticulocyte count
10
93.6
mean platelet volume
3
93
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 8
VGNC:2410
455818
Macaque
HAUS augmin like complex subunit 8
718874
Mouse
MGI:1923728
76478
Rat
RGD:1311565
290626
Dog
HAUS augmin like complex subunit 8
VGNC:41608
476677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 8
Macaque
HAUS augmin like complex subunit 8
Mouse
Rat
Dog
HAUS augmin like complex subunit 8
Publication Statistics
PubMed Score 1.65
PubMed score by year
PubTator Score 3.46
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title