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Tbio
LIMD2
LIM domain-containing protein 2

Protein Summary
Description
Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259006
  • ENSP00000259006
  • ENSG00000136490
  • ENST00000578061
  • ENSP00000464003
  • ENST00000578402
  • ENSP00000462707
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor perturbation
0.74
small molecule perturbation
0.73
histone modification site profile
0.71
cellular component
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
87
body height
5
4
6
77.3
hemoglobin measurement
1
1
1
73.9
IGF-1 measurement
1
1
1
73.7
red blood cell density measurement
1
1
1
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
87
body height
6
77.3
hemoglobin measurement
1
73.9
IGF-1 measurement
1
73.7
red blood cell density measurement
1
71.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LIM domain containing 2
717889
Mouse
MGI:1915053
67803
Rat
RGD:1309967
360646
Dog
LIM domain containing 2
VGNC:42680
610728
Horse
LIM domain containing 2
VGNC:19670
100054185
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LIM domain containing 2
Mouse
Rat
Dog
LIM domain containing 2
Horse
LIM domain containing 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BT23-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
GRAP
Tbio
Novelty:  0.01934633
Score:  0.768
Data Source:  STRINGDB
PDLIM2
Tbio
Novelty:  0.03761867
Score:  0.718
Data Source:  STRINGDB
EYA3
Tbio
Novelty:  0.05588286
Score:  0.619
Data Source:  STRINGDB
FHL2
Tbio
Novelty:  0.00501273
Score:  0.541
Data Source:  STRINGDB
SDAD1
Tdark
Novelty:  0.2574139
Score:  0.531
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.514
Data Source:  STRINGDB
SPATS2
Tdark
Novelty:  0.20594325
Score:  0.506
Data Source:  STRINGDB
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
Score:  0.505
Data Source:  STRINGDB
TMA7
Tdark
Novelty:  0.11174801
Score:  0.504
Data Source:  STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
Score:  0.499
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.31

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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