ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase
Protein Summary
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]
- ENST00000262374
- ENSP00000262374
- ENSG00000033011
- ENST00000544428
- ENSP00000440019
- ENST00000588623
- ENSP00000468118
- HMAT1
- HMT1
- HMT1
- MT-1
- CDG1K
- HMAT1
- HMT-1
- Mat-1
- hMat-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
tissue sample | 0.7 | ||
interacting protein | 0.66 | ||
cellular component | 0.6 | ||
transcription factor binding site profile | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.94 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.94 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0