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Tdark
TSEN34
tRNA-splicing endonuclease subunit Sen34

Protein Summary
Description
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. This gene encodes a catalytic subunit of the tRNA splicing endonuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302937
  • ENSP00000305524
  • ENSG00000170892
  • ENST00000396383
  • ENSP00000379667
  • ENST00000396388
  • ENSP00000379671
  • ENST00000611560
  • ENSP00000480422
  • ENSG00000274796
  • ENST00000611798
  • ENSP00000480899
  • ENSG00000278605
  • ENST00000612236
  • ENSP00000480503
  • ENSG00000274129
  • ENST00000612393
  • ENSP00000478622
  • ENSG00000278622
  • ENST00000613310
  • ENSP00000477766
  • ENSG00000274078
  • ENST00000613712
  • ENSP00000484865
  • ENSG00000273896
  • ENST00000613888
  • ENSP00000481068
  • ENSG00000278712
  • ENST00000614948
  • ENSP00000478156
  • ENST00000614984
  • ENSP00000483266
  • ENST00000615000
  • ENSP00000479654
  • ENST00000615079
  • ENSP00000484694
  • ENST00000615900
  • ENSP00000484964
  • ENST00000615975
  • ENSP00000484225
  • ENST00000616063
  • ENSP00000480964
  • ENST00000616209
  • ENSP00000481374
  • ENSG00000274672
  • ENST00000617149
  • ENSP00000481639
  • ENST00000617902
  • ENSP00000484465
  • ENSG00000275165
  • ENST00000618135
  • ENSP00000479576
  • ENST00000619994
  • ENSP00000482084
  • ENST00000622524
  • ENSP00000483436
  • ENST00000622538
  • ENSP00000482527

Symbol
  • LENG5
  • SEN34
  • LENG5
  • PCH2C
  • SEN34
  • SEN34L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.97
kinase perturbation
0.95
histone modification site profile
0.86
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (328)
Items per page:
1 – 5 of 328
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
creatine kinase measurement
5
5
9
96.9
Items per page:
1 – 5 of 328
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
creatine kinase measurement
9
96.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 34
VGNC:11454
107969802
Macaque
tRNA splicing endonuclease subunit 34
693919
Mouse
MGI:1913328
66078
Dog
tRNA splicing endonuclease subunit 34
VGNC:47896
611457
Horse
tRNA splicing endonuclease subunit 34
VGNC:51087
100052851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 34
Macaque
tRNA splicing endonuclease subunit 34
Mouse
Dog
tRNA splicing endonuclease subunit 34
Horse
tRNA splicing endonuclease subunit 34
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BSV6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (38)
1 – 10 of 38
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.999608957
p_ni:  0.000391043
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.999398625
p_ni:  0.000601375
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSEN54
Tbio
Family:  Enzyme
Novelty:  0.03157812
Score:  0.998
Data Source:  STRINGDB
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
Score:  0.965
Data Source:  STRINGDB
CSTF2
Tbio
Novelty:  0.01389909
Score:  0.906
Data Source:  STRINGDB
CPSF4
Tbio
Novelty:  0.00206207
Score:  0.904
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.902
Data Source:  STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
Score:  0.87
Data Source:  STRINGDB
LENG1
Tdark
Novelty:  1.81219077
Score:  0.724
Data Source:  STRINGDB
VRK1
Tbio
Family:  Kinase
Novelty:  0.00761136
Score:  0.717
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.64

PubMed score by year
PubTator Score  3.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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