Tbio UBAC1 Ubiquitin-associated domain-containing protein 1

Protein Summary

Description

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Uniprot Accession IDs

• Q9BSL1
• O75500
• Q9UMW7
• UBA domain-containing protein 1

Gene Name

• UBAC1

Ensembl ID

• ENST00000371756
• ENSP00000360821
• ENSG00000130560

Symbol

• GBDR1
• KPC2
• UBADC1
• KPC2
• GBDR1
• UBADC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
virus perturbation	0.92
gene perturbation	0.9
cell type or tissue	0.81
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1127.26   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1127.26   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0