Tbio ESYT1 Extended synaptotagmin-1

Protein Summary

Description

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.

Uniprot Accession IDs

• Q9BSJ8
• A0FGR7
• A8K2S2
• O94848
• Q6PJN4
• Q9H6J1
• Q9H6W2
• Q9Y416
• E-Syt1

Gene Name

• ESYT1

Ensembl ID

• ENST00000267113
• ENSP00000267113
• ENSG00000139641
• ENST00000394048
• ENSP00000377612

Symbol

• FAM62A
• KIAA0747
• MBC2
• MBC2
• FAM62A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.95
transcription factor binding site profile	0.93
transcription factor perturbation	0.91
transcription factor	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.64   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.64   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0