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Tbio
ESYT1
Extended synaptotagmin-1

Protein Summary
Description
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267113
  • ENSP00000267113
  • ENSG00000139641
  • ENST00000394048
  • ENSP00000377612

Symbol
  • FAM62A
  • KIAA0747
  • MBC2
  • MBC2
  • FAM62A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.95
transcription factor binding site profile
0.93
transcription factor perturbation
0.91
transcription factor
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.61   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.61   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
extended synaptotagmin 1
711720
Mouse
MGI:1344426
23943
Rat
RGD:3053
29579
Dog
extended synaptotagmin 1
VGNC:40483
474397
Horse
extended synaptotagmin 1
VGNC:17690
100051975
Species
Name
OMA
EggNOG
Inparanoid
Macaque
extended synaptotagmin 1
Mouse
Rat
Dog
extended synaptotagmin 1
Horse
extended synaptotagmin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BSJ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (70)
1 – 10 of 70
TSPAN11
Tdark
Novelty: 0.37247094
p_int: 0.99934484
p_ni: 0.00065516
Score: 0.318
Data Source: BioPlex,STRINGDB
ANKRD22
Tdark
Novelty: 0.28856283
p_int: 0.998381242
p_ni: 0.001618758
Data Source: BioPlex
SYNJ2BP
Tbio
Novelty: 0.02520087
p_int: 0.982559476
p_ni: 0.017440524
Score: 0.488
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.969390359
p_ni: 0.030609641
Data Source: BioPlex
UGT1A9
Tbio
Family: Enzyme
Novelty: 0.0047848
p_int: 0.94031702
p_ni: 0.05968298
Score: 0.252
Data Source: BioPlex,STRINGDB
SCGN
Tbio
Novelty: 0.01434518
p_int: 0.94000728
p_ni: 0.05999272
Score: 0.195
Data Source: BioPlex,STRINGDB
KCNC4
Tclin
Family: IC
Novelty: 0.01215128
p_int: 0.861253492
p_ni: 0.138746508
Data Source: BioPlex
ESYT2
Tbio
Novelty: 0.04545794
Score: 0.986
Data Source: Reactome,STRINGDB
ESYT3
Tbio
Novelty: 0.08038584
Score: 0.944
Data Source: Reactome,STRINGDB
YIF1B
Tbio
Novelty: 0.06478298
Score: 0.889
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.61

PubMed score by year
PubTator Score  15.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer