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Tbio
TACO1
Translational activator of cytochrome c oxidase 1

Protein Summary
Description
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258975
  • ENSP00000258975
  • ENSG00000136463

Symbol
  • CCDC44
  • CCDC44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.9
protein domain
0.73
cell line
0.58
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
CYCS
Tchem
Novelty:  0.00014004
Score:  0.942
Data Source:  STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
Score:  0.861
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.83
Data Source:  STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.825
Data Source:  STRINGDB
COA3
Tbio
Family:  Enzyme
Novelty:  0.04949473
Score:  0.824
Data Source:  STRINGDB
MSS51
Tbio
Novelty:  0.06388791
Score:  0.774
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.76
Data Source:  STRINGDB
GFM1
Tbio
Novelty:  0.00503994
Score:  0.754
Data Source:  STRINGDB
PTCD1
Tdark
Novelty:  0.17182155
Score:  0.753
Data Source:  STRINGDB
COX14
Tbio
Family:  Enzyme
Novelty:  0.09340462
Score:  0.751
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
4
6
77.3
body mass index
3
2
3
72.1
waist-hip ratio
2
2
2
69.6
mean corpuscular volume
1
1
1
49.5
BMI-adjusted waist circumference
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
77.3
body mass index
3
72.1
waist-hip ratio
2
69.6
mean corpuscular volume
1
49.5
BMI-adjusted waist circumference
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translational activator of cytochrome c oxidase I
VGNC:10049
738517
Mouse
MGI:1917457
70207
Rat
RGD:1306784
360645
Dog
translational activator of cytochrome c oxidase I
VGNC:47065
100856685
Horse
translational activator of cytochrome c oxidase I
VGNC:23840
100054228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translational activator of cytochrome c oxidase I
Mouse
Rat
Dog
translational activator of cytochrome c oxidase I
Horse
translational activator of cytochrome c oxidase I
Publication Statistics
PubMed Score 9.77
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title