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Tdark
C2orf88
Small membrane A-kinase anchor protein

Protein Summary
Description
Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340623
  • ENSP00000345107
  • ENSG00000187699
  • ENST00000396974
  • ENSP00000380172
  • ENST00000409870
  • ENSP00000386649
  • ENST00000443551
  • ENSP00000405225

Symbol
  • smAKAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.33   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.33   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (20)
1 – 10 of 20
AKAP10
Tbio
Family:  Enzyme
Novelty:  0.03517248
Score:  0.787
Data Source:  STRINGDB
NEMP2
Tdark
Novelty:  1.47547409
Score:  0.711
Data Source:  STRINGDB
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
Score:  0.616
Data Source:  STRINGDB
OSGEPL1
Tbio
Family:  Enzyme
Novelty:  0.13592288
Score:  0.588
Data Source:  STRINGDB
ORMDL1
Tbio
Novelty:  0.1323746
Score:  0.582
Data Source:  STRINGDB
AKAP7
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.569
Data Source:  STRINGDB
AKAP7
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.569
Data Source:  STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
Score:  0.559
Data Source:  STRINGDB
ASDURF
Tdark
Novelty:  0.54006324
Score:  0.558
Data Source:  STRINGDB
ASNSD1
Tdark
Family:  Enzyme
Novelty:  0.54006324
Score:  0.558
Data Source:  STRINGDB
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
50.6
reticulocyte count
2
1
2
48.5
ferritin measurement
1
1
1
42.3
sleep duration
1
1
1
1.1
triglyceride measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
50.6
reticulocyte count
2
48.5
ferritin measurement
1
42.3
sleep duration
1
1.1
triglyceride measurement
1
1.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 2B C2orf88 homolog
VGNC:14499
745558
Mouse
MGI:1914330
67080
Rat
RGD:1596493
685203
Dog
chromosome 37 C2orf88 homolog
VGNC:52561
100685423
Horse
chromosome 18 C2orf88 homolog
VGNC:51442
100054557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 2B C2orf88 homolog
Mouse
Rat
Dog
chromosome 37 C2orf88 homolog
Horse
chromosome 18 C2orf88 homolog
Publication Statistics
PubMed Score 2.33
PubMed score by year
PubTator Score 1.89
PubTator score by year