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Tbio
ATG101
Autophagy-related protein 101

Protein Summary
Description
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336854
  • ENSP00000338990
  • ENSG00000123395

Symbol
  • C12orf44
  • C12orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.76
transcription factor
0.72
cell line
0.55
tissue sample
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
RB1CC1
Tbio
Novelty:  0.00744817
p_int:  0.999999925
p_ni:  7.4e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ATG13
Tbio
Novelty:  0.00951471
p_int:  0.99999987
p_ni:  1.9e-8
p_wrong:  1.11e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ULK1
Tchem
Family:  Kinase
Novelty:  0.00240301
p_int:  0.999999004
p_ni:  9.94e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CNTLN
Tbio
Novelty:  0.0044959
p_int:  0.999994303
p_ni:  0.000005534
p_wrong:  1.63e-7
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999988929
p_ni:  0.000011071
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.994766999
p_ni:  0.005233001
Data Source:  BioPlex
FAM221B
Tdark
Novelty:  71
p_int:  0.994271169
p_ni:  4.4e-8
p_wrong:  0.005728787
Score:  0.403
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.993625929
p_ni:  1e-7
p_wrong:  0.006373971
Score:  0.214
Data Source:  BioPlex,STRINGDB
ULK2
Tchem
Family:  Kinase
Novelty:  0.02285321
p_int:  0.946081167
p_ni:  2.2e-8
p_wrong:  0.053918811
Score:  0.99
Data Source:  BioPlex,STRINGDB
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.94202008
p_ni:  0.057979402
p_wrong:  5.18e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
90.3
mean corpuscular hemoglobin concentration
1
1
1
82
red blood cell density measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
90.3
mean corpuscular hemoglobin concentration
1
82
red blood cell density measurement
1
48.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 101
VGNC:4940
451914
Macaque
autophagy related 101
696954
Mouse
MGI:1915368
68118
Rat
RGD:1359310
300240
Dog
autophagy related 101
VGNC:38215
486535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 101
Macaque
autophagy related 101
Mouse
Rat
Dog
autophagy related 101
Publication Statistics
PubMed Score 21.55
PubMed score by year
PubTator Score 6.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title