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Tbio
ATG101
Autophagy-related protein 101

Protein Summary
Description
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336854
  • ENSP00000338990
  • ENSG00000123395

Symbol
  • C12orf44
  • C12orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.76
transcription factor
0.72
cell line
0.55
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
79.6
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (53)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (105)
1 – 10 of 105
RB1CC1
Tbio
Novelty: 0.00744817
p_int: 0.999999925
p_ni: 7.4e-8
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ATG13
Tbio
Novelty: 0.00951471
p_int: 0.99999987
p_ni: 1.9e-8
p_wrong: 1.11e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
p_int: 0.999999004
p_ni: 9.94e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CNTLN
Tbio
Novelty: 0.0044959
p_int: 0.999994303
p_ni: 0.000005534
p_wrong: 1.63e-7
Data Source: BioPlex
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999988929
p_ni: 0.000011071
Data Source: BioPlex
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.994766999
p_ni: 0.005233001
Data Source: BioPlex
FAM221B
Tdark
Novelty: 71
p_int: 0.994271169
p_ni: 4.4e-8
p_wrong: 0.005728787
Score: 0.403
Data Source: BioPlex,STRINGDB
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.993625929
p_ni: 1e-7
p_wrong: 0.006373971
Score: 0.214
Data Source: BioPlex,STRINGDB
ULK2
Tchem
Family: Kinase
Novelty: 0.02285321
p_int: 0.946081167
p_ni: 2.2e-8
p_wrong: 0.053918811
Score: 0.99
Data Source: BioPlex,STRINGDB
HSBP1
Tbio
Novelty: 0.09422832
p_int: 0.94202008
p_ni: 0.057979402
p_wrong: 5.18e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  19.83

PubMed score by year
PubTator Score  6.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer