Tbio TMEM175 Endosomal/lysosomal potassium channel TMEM175

Protein Summary

Description

Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.

Uniprot Accession IDs

• Q9BSA9
• D3DVN4
• Q8ND13

Gene Name

• TMEM175

Ensembl ID

• ENST00000264771
• ENSP00000264771
• ENSG00000127419
• ENST00000515740
• ENSP00000427039
• ENST00000622959
• ENSP00000485461

Symbol

• hTMEM175

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.67
kinase perturbation	0.66
tissue sample	0.63
transcription factor binding site profile	0.62
cell line	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0