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Tbio
TMEM175
Endosomal/lysosomal potassium channel TMEM175

Protein Summary
Description
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264771
  • ENSP00000264771
  • ENSG00000127419
  • ENST00000515740
  • ENSP00000427039
  • ENST00000622959
  • ENSP00000485461

Symbol
  • hTMEM175
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
kinase perturbation
0.66
tissue sample
0.63
transcription factor binding site profile
0.62
cell line
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.4   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.4   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
14
22
99.7
10
7
2
1.2
98
waist-hip ratio
3
10
10
91.2
BMI-adjusted waist-hip ratio
3
9
10
90.7
bone density
4
5
5
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
22
99.7
2
1.2
98
waist-hip ratio
10
91.2
BMI-adjusted waist-hip ratio
10
90.7
bone density
5
90.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 175
696545
Mouse
MGI:1919642
72392
Rat
RGD:1309712
305623
Dog
transmembrane protein 175
VGNC:47500
100682837
Horse
transmembrane protein 175
VGNC:24224
100051913
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 175
Mouse
Rat
Dog
transmembrane protein 175
Horse
transmembrane protein 175
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BSA9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (22)
1 – 10 of 22
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999668055
p_ni:  0.000007142
p_wrong:  0.000324803
Data Source:  BioPlex
TMEM154
Tdark
Novelty:  0.08935925
p_int:  0.997823158
p_ni:  2.28e-7
p_wrong:  0.002176614
Data Source:  BioPlex
DGKQ
Tbio
Family:  Kinase
Novelty:  0.01973121
Score:  0.695
Data Source:  STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
Score:  0.694
Data Source:  STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.672
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.643
Data Source:  STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
Score:  0.59
Data Source:  STRINGDB
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
Score:  0.553
Data Source:  STRINGDB
FAM193A
Tdark
Novelty:  0.35264727
Score:  0.53
Data Source:  STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
Score:  0.524
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.40

PubMed score by year
PubTator Score  4.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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