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Tbio
TTYH2
Protein tweety homolog 2

Protein Summary
Description
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269346
  • ENSP00000269346
  • ENSG00000141540
  • ENST00000441391
  • ENSP00000394576

Symbol
  • C17orf29
  • C17orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
kinase perturbation
0.91
transcription factor
0.75
transcription factor binding site profile
0.7
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999996199
p_ni:  4.11e-7
p_wrong:  0.00000339
Score:  0.189
Data Source:  BioPlex,STRINGDB
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.905732661
p_ni:  0.000080391
p_wrong:  0.094186948
Data Source:  BioPlex
ERMN
Tbio
Novelty:  0.05302803
Score:  0.729
Data Source:  STRINGDB
CLIC2
Tbio
Family:  IC
Novelty:  0.03695725
Score:  0.727
Data Source:  STRINGDB
CCDC137
Tdark
Novelty:  1.16145052
Score:  0.708
Data Source:  STRINGDB
BEST4
Tbio
Family:  IC
Novelty:  0.06102944
Score:  0.666
Data Source:  STRINGDB
BEST2
Tbio
Family:  IC
Novelty:  0.03182837
Score:  0.661
Data Source:  STRINGDB
ANO2
Tchem
Family:  IC
Novelty:  0.01239394
Score:  0.657
Data Source:  STRINGDB
BEST3
Tbio
Family:  IC
Novelty:  0.03481733
Score:  0.653
Data Source:  STRINGDB
ANO1
Tclin
Family:  IC
Novelty:  0.00143722
Score:  0.649
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tweety family member 2
VGNC:9752
743958
Macaque
tweety family member 2
701738
Mouse
MGI:2157091
117160
Rat
RGD:1562969
287803
Dog
tweety family member 2
VGNC:49681
106559221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tweety family member 2
Macaque
tweety family member 2
Mouse
Rat
Dog
tweety family member 2
Publication Statistics
PubMed Score 6.91
PubMed score by year
PubTator Score 3.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title