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Tbio
LXN
Latexin

Protein Summary
Description
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264265
  • ENSP00000264265
  • ENSG00000079257

Symbol
  • ECI
  • TCI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
kinase perturbation
0.88
gene perturbation
0.85
cell type or tissue
0.74
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.42   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 555   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.42   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 555   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
47.7
systolic blood pressure
1
1
1
42.3
electrocardiography
1
1
3
21
smoking status measurement
2
1
2
21
vital capacity
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
47.7
systolic blood pressure
1
42.3
electrocardiography
3
21
smoking status measurement
2
21
vital capacity
1
13.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
latexin
VGNC:1867
100615227
Macaque
latexin
703996
Mouse
MGI:107633
17035
Rat
RGD:68361
59073
Dog
latexin
VGNC:42871
610062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
latexin
Macaque
latexin
Mouse
Rat
Dog
latexin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BS40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (31)
1 – 10 of 31
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
Score:  0.922
Data Source:  STRINGDB
CPA2
Tchem
Family:  Enzyme
Novelty:  0.01066441
Score:  0.757
Data Source:  STRINGDB
AGBL2
Tchem
Family:  Enzyme
Novelty:  0.00485282
Score:  0.702
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.691
Data Source:  STRINGDB
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.632
Data Source:  STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
Score:  0.623
Data Source:  STRINGDB
GKN2
Tbio
Novelty:  0.03273017
Score:  0.555
Data Source:  STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
Score:  0.545
Data Source:  STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.523
Data Source:  STRINGDB
MED15
Tbio
Family:  Enzyme
Novelty:  0.01641057
Score:  0.518
Data Source:  STRINGDB
Publication Statistics
PubMed Score  86.42

PubMed score by year
PubTator Score  193.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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