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Tbio
ANAPC13
Anaphase-promoting complex subunit 13

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354910
  • ENSP00000346987
  • ENSG00000129055
  • ENST00000510994
  • ENSP00000421842
  • ENST00000511751
  • ENSP00000421760
  • ENST00000514612
  • ENSP00000427327

Symbol
  • SWM1
  • APC13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.85
kinase perturbation
0.84
transcription factor binding site profile
0.81
microRNA
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.68   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.68   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
p_int:  0.999999929
p_ni:  7.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999999852
p_ni:  1.45e-7
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
p_int:  0.999999829
p_ni:  1.71e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.999999684
p_ni:  3.16e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.999998604
p_ni:  0.000001395
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.999998592
p_ni:  0.000001407
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.999994955
p_ni:  0.000005045
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.999992953
p_ni:  0.000007047
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC7
Tbio
Family:  Enzyme
Novelty:  0.17956785
p_int:  0.999780961
p_ni:  0.000219039
Score:  0.999
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.999670686
p_ni:  0.000329314
Score:  0.995
Data Source:  BioPlex,STRINGDB
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
3
9
68.8
smoking behavior
1
1
2
55.2
body height
1
1
1
27.2
BMI-adjusted hip circumference
1
1
1
17.8
red blood cell distribution width
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
9
68.8
smoking behavior
2
55.2
body height
1
27.2
BMI-adjusted hip circumference
1
17.8
red blood cell distribution width
1
12
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 13
VGNC:1733
460984
Macaque
anaphase promoting complex subunit 13
717294
Mouse
MGI:1916260
69010
Rat
RGD:1583270
685029
Dog
anaphase promoting complex subunit 13
VGNC:37846
609033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 13
Macaque
anaphase promoting complex subunit 13
Mouse
Rat
Dog
anaphase promoting complex subunit 13
Publication Statistics
PubMed Score 15.68
PubMed score by year
PubTator Score 5.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title