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Tbio
CENPK
Centromere protein K

Protein Summary
Description
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242872
  • ENSP00000242872
  • ENSG00000123219
  • ENST00000396679
  • ENSP00000379911
  • ENST00000514814
  • ENSP00000422421

Symbol
  • ICEN37
  • P33
  • Solt
  • CENP-K
  • FKSG14
  • AF5alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
small molecule perturbation
0.79
transcription factor perturbation
0.61
biological process
0.51
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (206)
1 – 10 of 206
CENPH
Tbio
Novelty:  0.02845079
Score:  0.997
Data Source:  Reactome,STRINGDB
CENPL
Tbio
Novelty:  0.18429095
Score:  0.994
Data Source:  STRINGDB
CENPU
Tbio
Novelty:  0.03681625
Score:  0.994
Data Source:  STRINGDB
CENPN
Tbio
Novelty:  0.06923443
Score:  0.994
Data Source:  STRINGDB
CENPI
Tbio
Novelty:  0.01938121
Score:  0.994
Data Source:  Reactome,STRINGDB
CENPQ
Tbio
Novelty:  0.19972678
Score:  0.992
Data Source:  STRINGDB
CENPO
Tbio
Novelty:  0.12059767
Score:  0.992
Data Source:  STRINGDB
ITGB3BP
Tbio
Novelty:  0.06162186
Score:  0.99
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.985
Data Source:  STRINGDB
CENPM
Tbio
Novelty:  0.0671332
Score:  0.985
Data Source:  STRINGDB
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
2.8
53.7
BMI-adjusted waist circumference
2
2
2
39.4
feeling tense measurement
1
1
0
6
31.4
aspartate aminotransferase measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.8
53.7
BMI-adjusted waist circumference
2
39.4
feeling tense measurement
0
6
31.4
aspartate aminotransferase measurement
1
29
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein K
VGNC:3946
743390
Macaque
centromere protein K
696142
Mouse
MGI:1926210
60411
Rat
RGD:1310461
294712
Dog
centromere protein K
VGNC:39106
609707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein K
Macaque
centromere protein K
Mouse
Rat
Dog
centromere protein K
Publication Statistics
PubMed Score 24.34
PubMed score by year
PubTator Score 4.97
PubTator score by year