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Tbio
TRIM56
E3 ubiquitin-protein ligase TRIM56

Protein Summary
Description
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306085
  • ENSP00000305161
  • ENSG00000169871

Symbol
  • RNF109
  • RNF109
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.85
histone modification site profile
0.82
transcription factor binding site profile
0.72
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.999999995
p_ni:  4e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
TMEM173
Tchem
Novelty:  0.0070581
Score:  0.967
Data Source:  Reactome,STRINGDB
TRIM32
Tbio
Family:  Enzyme
Novelty:  0.00103526
Score:  0.965
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.913
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.912
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.911
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.9
Data Source:  STRINGDB
LSM2
Tbio
Novelty:  0.03339237
Score:  0.812
Data Source:  STRINGDB
CGAS
Tchem
Family:  Enzyme
Novelty:  0.00239778
Score:  0.705
Data Source:  STRINGDB
TRIM38
Tbio
Family:  Enzyme
Novelty:  0.11210174
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of innate immune responses to cytosolic DNA
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Immune System
Innate Immune System
Regulation of innate immune responses to cytosolic DNA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
81.5
body mass index
1
1
1
44.2
plasminogen activator inhibitor 1 measurement
1
1
1
38.7
apolipoprotein A 1 measurement
1
1
1
38.2
body height
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
81.5
body mass index
1
44.2
plasminogen activator inhibitor 1 measurement
1
38.7
apolipoprotein A 1 measurement
1
38.2
body height
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 56
713833
Mouse
MGI:2685298
384309
Cow
tripartite motif containing 56
VGNC:36342
514896
Anole lizard
E3 ubiquitin-protein ligase TRIM56-like
100567036
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 56
Mouse
Cow
tripartite motif containing 56
Anole lizard
E3 ubiquitin-protein ligase TRIM56-like
Publication Statistics
PubMed Score 14.94
PubMed score by year
PubTator Score 5.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title