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Tchem
PRXL2A
Peroxiredoxin-like 2A

Protein Summary
Description
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372181
  • ENSP00000361254
  • ENSG00000122378
  • ENST00000372185
  • ENSP00000361259
  • ENST00000372187
  • ENSP00000361261
  • ENST00000372188
  • ENSP00000361262
  • ENST00000606162
  • ENSP00000482445
  • ENST00000615554
  • ENSP00000478152

Symbol
  • C10orf58
  • FAM213A
  • PAMM
  • Adrx
  • PAMM
  • FAM213A
  • C10orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
histone modification site profile
0.91
small molecule perturbation
0.88
transcription factor binding site profile
0.76
tissue sample
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ibrutinib
Rendered image for ibrutinib
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
77
monocyte count
1
1
1
70.5
1
1
0
1.1
69.8
myeloid white cell count
1
1
1
68.8
hematocrit
2
2
2
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77
monocyte count
1
70.5
0
1.1
69.8
myeloid white cell count
1
68.8
hematocrit
2
67.9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRX8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (43)
1 – 10 of 43
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.996349744
p_ni:  0.003650256
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.976773209
p_ni:  0.023226791
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.974127583
p_ni:  0.025871307
p_wrong:  0.000001111
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.95857731
p_ni:  0.04142269
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.948995473
p_ni:  0.051004527
Data Source:  BioPlex
A4GNT
Tbio
Family:  Enzyme
Novelty:  0.08971876
p_int:  0.946351336
p_ni:  0.053648664
Score:  0.191
Data Source:  BioPlex,STRINGDB
TLR5
Tbio
Novelty:  0.00110868
p_int:  0.945744261
p_ni:  0.054255739
Score:  0.211
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.941853172
p_ni:  0.058146828
Score:  0.204
Data Source:  BioPlex,STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
p_int:  0.904972635
p_ni:  0.094845457
p_wrong:  0.000181908
Data Source:  BioPlex
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.888624994
p_ni:  0.111375006
Score:  0.311
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  58.92

PubMed score by year
PubTator Score  3.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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