Protein Summary
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
- ENST00000372181
- ENSP00000361254
- ENSG00000122378
- ENST00000372185
- ENSP00000361259
- ENST00000372187
- ENSP00000361261
- ENST00000372188
- ENSP00000361262
- ENST00000606162
- ENSP00000482445
- ENST00000615554
- ENSP00000478152
- C10orf58
- FAM213A
- PAMM
- Adrx
- PAMM
- FAM213A
- C10orf58
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
histone modification site profile | 0.91 | ||
small molecule perturbation | 0.88 | ||
transcription factor binding site profile | 0.76 | ||
tissue sample | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.18 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.18 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1