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Tbio
GINS3
DNA replication complex GINS protein PSF3

Protein Summary
Description
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318129
  • ENSP00000318196
  • ENSG00000181938
  • ENST00000328514
  • ENSP00000327449
  • ENST00000426538
  • ENSP00000401018

Symbol
  • PSF3
  • PSF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.89
transcription factor perturbation
0.8
transcription factor binding site profile
0.72
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
GINS4
Tbio
Novelty:  0.0316194
p_int:  0.999999966
p_ni:  1.4e-8
p_wrong:  2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GINS1
Tbio
Novelty:  0.08722396
p_int:  0.999999336
p_ni:  6.64e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999998859
p_ni:  0.00000114
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CLSPN
Tbio
Novelty:  0.01330727
p_int:  0.999998208
p_ni:  0.00000154
p_wrong:  2.52e-7
Score:  0.748
Data Source:  BioPlex,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.999901282
p_ni:  0.000098718
Score:  0.937
Data Source:  BioPlex,STRINGDB
TIPIN
Tbio
Novelty:  0.03919376
p_int:  0.999284341
p_ni:  0.000715659
Score:  0.948
Data Source:  BioPlex,STRINGDB
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.994931709
p_ni:  0.005068291
Score:  0.999
Data Source:  BioPlex,STRINGDB
CSNK1G2
Tchem
Family:  Kinase
Novelty:  0.17930147
p_int:  0.993762599
p_ni:  0.006237401
Score:  0.819
Data Source:  BioPlex,STRINGDB
DNAJB3
Tdark
p_int:  0.992959802
p_ni:  0.007040067
p_wrong:  1.32e-7
Data Source:  BioPlex
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.959333623
p_ni:  0.040666377
Score:  0.799
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
DNA Replication
Reactome
DNA strand elongation
Reactome
S Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
DNA Replication
DNA strand elongation
S Phase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
2
8
91.8
TPE interval measurement
1
1
1
28.1
primary biliary cirrhosis
1
1
0
1.2
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
8
91.8
TPE interval measurement
1
28.1
primary biliary cirrhosis
0
1.2
1.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 3
VGNC:9080
454133
Macaque
GINS complex subunit 3
707142
Mouse
MGI:1926083
78833
Rat
RGD:1308153
307639
Dog
GINS complex subunit 3
VGNC:41222
487254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 3
Macaque
GINS complex subunit 3
Mouse
Rat
Dog
GINS complex subunit 3
Publication Statistics
PubMed Score 36.11
PubMed score by year
PubTator Score 16.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title