Tbio GINS3 DNA replication complex GINS protein PSF3

Protein Summary

Description

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BRX5
• B2RDP3
• E9PB21
• Q9H870

Gene Name

• GINS3

Ensembl ID

• ENST00000318129
• ENSP00000318196
• ENSG00000181938
• ENST00000328514
• ENSP00000327449
• ENST00000426538
• ENSP00000401018

Symbol

• PSF3
• PSF3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.89
transcription factor perturbation	0.8
transcription factor binding site profile	0.72
transcription factor	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.37   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.37   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0