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Tbio
PELO
Protein pelota homolog

Protein Summary
Description
Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274311
  • ENSP00000274311
  • ENSG00000152684

Symbol
  • CGI-17
  • PRO1770
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.91
histone modification site profile
0.78
disease perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
6
12
99.2
reticulocyte count
7
5
17
98.8
serum gamma-glutamyl transferase measurement
4
3
4
5.5
95.9
low density lipoprotein cholesterol measurement
5
4
5
93.1
apolipoprotein B measurement
2
2
2
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
12
99.2
reticulocyte count
17
98.8
serum gamma-glutamyl transferase measurement
4
5.5
95.9
low density lipoprotein cholesterol measurement
5
93.1
apolipoprotein B measurement
2
85.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pelota mRNA surveillance and ribosome rescue factor
VGNC:50804
104001088
Mouse
MGI:2145154
105083
Rat
RGD:1359591
294754
Horse
pelota mRNA surveillance and ribosome rescue factor
VGNC:21308
100052424
Cow
pelota mRNA surveillance and ribosome rescue factor
VGNC:32743
528728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pelota mRNA surveillance and ribosome rescue factor
Mouse
Rat
Horse
pelota mRNA surveillance and ribosome rescue factor
Cow
pelota mRNA surveillance and ribosome rescue factor
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BRX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
HBS1L
Tbio
Novelty:  0.00125579
Score:  0.993
Data Source:  STRINGDB
RACK1
Tbio
Novelty:  0.00200617
Score:  0.969
Data Source:  STRINGDB
ABCE1
Tbio
Family:  Transporter
Novelty:  0.00529126
Score:  0.959
Data Source:  STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.949
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.947
Data Source:  STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.943
Data Source:  STRINGDB
RPS28
Tbio
Novelty:  0.03303065
Score:  0.942
Data Source:  STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.928
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.924
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.43

PubMed score by year
PubTator Score  13.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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