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Tbio
GINS4
DNA replication complex GINS protein SLD5

Protein Summary
Description
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276533
  • ENSP00000276533
  • ENSG00000147536
  • ENST00000518671
  • ENSP00000428754
  • ENST00000520710
  • ENSP00000429581

Symbol
  • SLD5
  • SLD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
ligand (protein) perturbation
0.83
transcription factor perturbation
0.74
disease perturbation
0.68
tissue sample
0.67


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 4
VGNC:12018
736437
Macaque
GINS complex subunit 4
703350
Mouse
MGI:1923847
109145
Rat
RGD:1307397
290842
Dog
GINS complex subunit 4
VGNC:41223
482843
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 4
Macaque
GINS complex subunit 4
Mouse
Rat
Dog
GINS complex subunit 4
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BRT9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
DNA Replication
Reactome
DNA strand elongation
Reactome
S Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
DNA Replication
DNA strand elongation
S Phase
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (123)
1 – 10 of 123
GINS3
Tbio
Novelty: 0.02892519
p_int: 0.999999966
p_ni: 1.4e-8
p_wrong: 2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GINS2
Tbio
Novelty: 0.0078966
p_int: 0.999999909
p_ni: 8.9e-8
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SIK1
Tchem
Family: Kinase
Novelty: 0.00523549
p_int: 0.999490659
p_ni: 0.000509341
Score: 0.264
Data Source: BioPlex,STRINGDB
CSNK1G2
Tchem
Family: Kinase
Novelty: 0.17930147
p_int: 0.997446164
p_ni: 0.002553836
Score: 0.666
Data Source: BioPlex,STRINGDB
LZIC
Tdark
Novelty: 0.34151594
p_int: 0.995392551
p_ni: 0.004607449
Score: 0.189
Data Source: BioPlex,STRINGDB
TIPIN
Tbio
Novelty: 0.03919376
p_int: 0.9908102
p_ni: 0.009189796
p_wrong: 4e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
MCM7
Tbio
Novelty: 0.0017984
p_int: 0.974092722
p_ni: 0.025907275
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.922054604
p_ni: 0.077944602
p_wrong: 7.94e-7
Data Source: BioPlex
TOX2
Tbio
Family: TF
Novelty: 0.02511477
p_int: 0.893498707
p_ni: 0.106501292
Score: 0.266
Data Source: BioPlex,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.878154526
p_ni: 0.121670728
p_wrong: 0.000174746
Score: 0.759
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  29.23

PubMed score by year
PubTator Score  7.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer