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Tbio
MIEN1
Migration and invasion enhancer 1

Protein Summary
Description
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394231
  • ENSP00000377778
  • ENSG00000141741

Symbol
  • C17orf37
  • RDX12
  • XTP4
  • C35
  • ORB3
  • XTP4
  • RDX12
  • C17orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.75
transcription factor
0.69
cell line
0.61
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
8
17
98.1
eosinophil percentage of leukocytes
2
3
3
96.4
7
6
0
1.2
95.1
alkaline phosphatase measurement
2
2
1
11.6
93.4
eosinophil count
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
17
98.1
eosinophil percentage of leukocytes
3
96.4
0
1.2
95.1
alkaline phosphatase measurement
1
11.6
93.4
eosinophil count
2
91.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
migration and invasion enhancer 1
VGNC:9380
746327
Mouse
MGI:1913678
103742
Rat
RGD:7553401
102552549
Dog
migration and invasion enhancer 1
VGNC:43228
480532
Horse
migration and invasion enhancer 1
VGNC:20180
100054686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
migration and invasion enhancer 1
Mouse
Rat
Dog
migration and invasion enhancer 1
Horse
migration and invasion enhancer 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BRT3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (40)
1 – 10 of 40
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.990567815
p_ni:  0.009432185
Data Source:  BioPlex
PGAP3
Tbio
Novelty:  0.01842385
Score:  0.913
Data Source:  STRINGDB
SELENOT
Tbio
Novelty:  0.02480242
Score:  0.84
Data Source:  STRINGDB
SELENOW
Tbio
Novelty:  0.00967095
Score:  0.802
Data Source:  STRINGDB
STARD3
Tbio
Novelty:  0.01540936
Score:  0.774
Data Source:  STRINGDB
GRB7
Tchem
Novelty:  0.0091833
Score:  0.733
Data Source:  STRINGDB
TCAP
Tbio
Novelty:  0.00623581
Score:  0.696
Data Source:  STRINGDB
PRDX1
Tchem
Novelty:  0.00207935
Score:  0.656
Data Source:  STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.635
Data Source:  STRINGDB
GPX1
Tbio
Family:  Enzyme
Novelty:  0.000826
Score:  0.634
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.07

PubMed score by year
PubTator Score  137.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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