Tbio MIEN1 Migration and invasion enhancer 1

Protein Summary

Description

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Uniprot Accession IDs

• Q9BRT3

Gene Name

• MIEN1

Ensembl ID

• ENST00000394231
• ENSP00000377778
• ENSG00000141741

Symbol

• C17orf37
• RDX12
• XTP4
• C35
• ORB3
• XTP4
• RDX12
• C17orf37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor binding site profile	0.75
transcription factor	0.69
cell line	0.61
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.04   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 415   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.04   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0