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Tbio
LARP6
La-related protein 6

Protein Summary
Description
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299213
  • ENSP00000299213
  • ENSG00000166173
  • ENST00000344870
  • ENSP00000343869

Symbol
  • ACHN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
protein domain
0.73
small molecule perturbation
0.69
virus perturbation
0.68
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.77   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.77   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  1
Score:  0.77
Data Source:  BioPlex,STRINGDB
FKBP3
Tbio
Family:  Enzyme
Novelty:  0.03166802
Score:  0.876
Data Source:  STRINGDB
RBM44
Tdark
Novelty:  0.77508772
Score:  0.711
Data Source:  STRINGDB
LARP4
Tbio
Novelty:  0.08499175
Score:  0.699
Data Source:  STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
Score:  0.697
Data Source:  STRINGDB
GMNC
Tbio
Novelty:  0.06300768
Score:  0.598
Data Source:  STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
Score:  0.592
Data Source:  STRINGDB
ACOT7
Tbio
Family:  Enzyme
Novelty:  0.01093954
Score:  0.578
Data Source:  STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.576
Data Source:  STRINGDB
RRBP1
Tbio
Novelty:  0.01494613
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 6
VGNC:3539
453549
Macaque
La ribonucleoprotein domain family member 6
699664
Mouse
MGI:1914807
67557
Rat
RGD:1308414
315731
Dog
La ribonucleoprotein domain family member 6
VGNC:42590
487625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 6
Macaque
La ribonucleoprotein domain family member 6
Mouse
Rat
Dog
La ribonucleoprotein domain family member 6
Publication Statistics
PubMed Score 23.77
PubMed score by year
PubTator Score 44.86
PubTator score by year
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Related Publications
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PMID
Year
Title