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Tchem
RIOK1
Serine/threonine-protein kinase RIO1

Protein Summary
Description
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379834
  • ENSP00000369162
  • ENSG00000124784

Symbol
  • RIO1
  • RIO1
  • AD034
  • RRP10
  • bA288G3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.9
histone modification site profile
0.87
small molecule
0.8
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999995974
p_ni: 0.000004026
Data Source: BioPlex
LSM6
Tbio
Novelty: 0.09507671
p_int: 0.99998531
p_ni: 0.00001469
Data Source: BioPlex
COPRS
Tbio
Novelty: 0.03545787
p_int: 0.999960062
p_ni: 0.000039938
Score: 0.586
Data Source: BioPlex,STRINGDB
GAR1
Tbio
Novelty: 0.26091307
p_int: 0.99991938
p_ni: 0.000080619
p_wrong: 1e-9
Score: 0.398
Data Source: BioPlex,STRINGDB
TINAGL1
Tbio
Novelty: 0.05578199
p_int: 0.999879025
p_ni: 0.000120975
Score: 0.198
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
p_int: 0.999818595
p_ni: 0.000181405
Data Source: BioPlex
PPP1R14A
Tbio
Family: Enzyme
Novelty: 0.00231198
p_int: 0.999226335
p_ni: 0.000773657
p_wrong: 9e-9
Data Source: BioPlex
CHTOP
Tbio
Novelty: 0.04170391
p_int: 0.999033035
p_ni: 0.000966949
p_wrong: 1.6e-8
Data Source: BioPlex
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.99861159
p_ni: 0.00138841
Data Source: BioPlex
RPS2
Tbio
Novelty: 0.00412313
p_int: 0.995627939
p_ni: 0.004372061
Score: 0.986
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.90

PubMed score by year
PubTator Score  8.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer