Tbio ARHGAP9 Rho GTPase-activating protein 9

Protein Summary

Description

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BRR9
• B4DVI3
• E9PDX9
• Q8NAF3
• Q8TCJ3
• Q8WYR0
• Q96EZ2
• Q96S74

Gene Name

• ARHGAP9

Ensembl ID

• ENST00000393791
• ENSP00000377380
• ENSG00000123329
• ENST00000424809
• ENSP00000394307
• ENST00000430041
• ENSP00000397950

Symbol

• 10C
• RGL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cell type or tissue	0.76
cell line	0.71
tissue	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 9

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.97   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.97   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0