Tbio ZKSCAN3 Zinc finger protein with KRAB and SCAN domains 3

Protein Summary

Description

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.

Uniprot Accession IDs

• Q9BRR0
• B2R8W2
• B3KVC0
• H7BXX1
• Q5VXH3
• Q92972
• Q9H4T3

Gene Name

• ZKSCAN3

Ensembl ID

• ENST00000252211
• ENSP00000252211
• ENSG00000189298
• ENST00000341464
• ENSP00000341883
• ENST00000377255
• ENSP00000366465

Symbol

• ZFP47
• ZNF306
• ZNF309
• ZSCAN13
• ZF47
• Zfp47
• ZFP306
• ZNF306
• ZNF309
• zfp-47
• ZSCAN13
• ZSCAN35
• dJ874C20.1
• dJ874C20.1.

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.93
molecular function	0.9
disease perturbation	0.87
protein domain	0.85
kinase perturbation	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.92   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.92   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0