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Tbio
ZKSCAN3
Zinc finger protein with KRAB and SCAN domains 3

Protein Summary
Description
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252211
  • ENSP00000252211
  • ENSG00000189298
  • ENST00000341464
  • ENSP00000341883
  • ENST00000377255
  • ENSP00000366465

Symbol
  • ZFP47
  • ZNF306
  • ZNF309
  • ZSCAN13
  • ZF47
  • Zfp47
  • ZFP306
  • ZNF306
  • ZNF309
  • zfp-47
  • ZSCAN13
  • ZSCAN35
  • dJ874C20.1
  • dJ874C20.1.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
molecular function
0.9
disease perturbation
0.87
protein domain
0.85
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999999914
p_ni:  8.6e-8
Score:  0.742
Data Source:  BioPlex,STRINGDB
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.999999896
p_ni:  1.04e-7
Score:  0.821
Data Source:  BioPlex,STRINGDB
ZKSCAN4
Tbio
Family:  TF
Novelty:  0.33154485
p_int:  0.999999298
p_ni:  7.01e-7
Score:  0.866
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999999249
p_ni:  7.51e-7
Score:  0.691
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.999999192
p_ni:  8.08e-7
Data Source:  BioPlex
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999986581
p_ni:  0.000013419
Score:  0.812
Data Source:  BioPlex,STRINGDB
ZNF396
Tbio
Family:  TF
Novelty:  0.95895478
p_int:  0.999985386
p_ni:  0.000014614
Score:  0.826
Data Source:  BioPlex,STRINGDB
ZNF483
Tdark
Family:  TF
Novelty:  0.39891191
p_int:  0.999917743
p_ni:  0.000082257
Score:  0.728
Data Source:  BioPlex,STRINGDB
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.999487232
p_ni:  0.00051268
p_wrong:  8.9e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.998246183
p_ni:  0.000631147
p_wrong:  0.00112267
Score:  0.294
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.3
94.5
wellbeing measurement
3
4
4
89.6
major depressive disorder
2
2
1
8.9
86.6
peak expiratory flow
1
1
1
83.9
2
2
0
5
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
94.5
wellbeing measurement
4
89.6
major depressive disorder
1
8.9
86.6
peak expiratory flow
1
83.9
0
5
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger with KRAB and SCAN domains 3
VGNC:11690
462519
Macaque
zinc finger with KRAB and SCAN domains 3
707581
Mouse
MGI:1919989
72739
Rat
RGD:1305753
306977
Dog
zinc finger with KRAB and SCAN domains 4
100682684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger with KRAB and SCAN domains 3
Macaque
zinc finger with KRAB and SCAN domains 3
Mouse
Rat
Dog
zinc finger with KRAB and SCAN domains 4
Publication Statistics
PubMed Score 19.70
PubMed score by year
PubTator Score 7.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title